ArticleHeredity2013
Searching for the bull's eye: agents and targets of selection vary among geographically disparate cyanogenesis clines in white clover (Trifolium repens L.).
Article in Heredity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Evolution of drought resistance strategies following the introduction of white clover (Trifolium repens L.).Annals of botany · 2025Article
- Haploblocks contribute to parallel climate adaptation following global invasion of a cosmopolitan plant.Nature ecology & evolution · 2025Article
- Herbivory and water availability interact to shape the adaptive landscape in the perennial forb, Boechera stricta.Evolution; international journal of organic evolution · 2025Article
- De novo genome assembly of white clover (Trifolium repens L.) reveals the role of copy number variation in rapid environmental adaptation.BMC biology · 2024Article
- Introduced species shed friends as well as enemies.Scientific reports · 2024Article
- Haplotype-Resolved, Chromosome-Level Assembly of White Clover (Trifolium repens L., Fabaceae).Genome biology and evolution · 2023Article
- Assessing the Benefits and Costs of the Hydrogen Cyanide Antiherbivore Defense inPlants (Basel, Switzerland) · 2023Article
- Outlier analyses and genome-wide association study identifyFrontiers in plant science · 2022Article
- Predicting the strength of urban-rural clines in a Mendelian polymorphism along a latitudinal gradient.Evolution letters · 2020Article
- Getting ahead of the curve: cities as surrogates for global change.Proceedings. Biological sciences · 2018Review
- Modern spandrels: the roles of genetic drift, gene flow and natural selection in the evolution of parallel clines.Proceedings. Biological sciences · 2018Article
- Urbanization drives the evolution of parallel clines in plant populations.Proceedings. Biological sciences · 2016Article
- Adaptive gains through repeated gene loss: parallel evolution of cyanogenesis polymorphisms in the genus Trifolium (Fabaceae).Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The recurrent evolution of adaptive clines within a species can be used to elucidate the selective factors and genetic responses that underlie adaptation. White clover is polymorphic for cyanogenesis (HCN release with tissue damage), and climate-associated cyanogenesis clines have evolved throughout the native and introduced species range. This polymorphism arises through two independently segregating Mendelian polymorphisms for the presence/absence of two required components: cyanogenic glucosides and their hydrolyzing enzyme linamarase. Cyanogenesis is commonly thought to function in herbivore defense; however, the individual cyanogenic components may also serve other physiological functions. To test whether cyanogenesis clines have evolved in response to the same selective pressures acting on the same genetic targets, we examined cyanogenesis cline shape and its environmental correlates in three world regions: southern New Zealand, the central United States and the US Pacific Northwest. For some regional comparisons, cline shapes are remarkably similar despite large differences in the spatial scales over which clines occur (40-1600 km). However, we also find evidence for major differences in both the agents and targets of selection among the sampled clines. Variation in cyanogenesis frequency is best predicted using a combination of minimum winter temperature and aridity variables. Together, our results provide evidence that recurrent adaptive clines do not necessarily reflect shared adaptive processes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.