Evidence map›Paper›PMID 23900355›Full record

ReviewNature reviews. Cardiology2013

Dilated cardiomyopathy: the complexity of a diverse genetic architecture.

Ray E Hershberger, Dale J Hedges, Ana Morales

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 553 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
553citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

553 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Geographical and Ethnic Heterogeneity in Genetic Dilated Cardiomyopathies.International journal of molecular sciences · 2026
    Pooled it
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  9. Efficacy and Safety of ARRY-371797 inCirculation. Genomic and precision medicine · 2023
    Trial
  10. Functional analysis ofMolecular therapy. Nucleic acids · 2026
    Article
  11. Observational
  12. Review
  13. Article
  14. Article
  15. Review
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  17. Review
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  19. A highly penetrantbioRxiv : the preprint server for biology · 2026
    Article
  20. Article

493 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ray E HershbergerDivision of Human Genetics, The Ohio State University College of Medicine, 460 West 12th Avenue, Columbus, OH 43210, USA. ray.hershberger@osumc.edu
Dale J Hedges
Ana Morales

Funding

FAMILIAL DILATED CARDIOMYOPATHY--DETECTION/GENE MAPPINGR01HL058626 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI HERSHBERGER, RAY E. · 1998 to 2011
$6.0M
NHLBI NIH HHS HL58626NHLBI NIH HHS R01 HL058626
6 · The paper itself

Abstract

Remarkable progress has been made in understanding the genetic basis of dilated cardiomyopathy (DCM). Rare variants in >30 genes, some also involved in other cardiomyopathies, muscular dystrophy, or syndromic disease, perturb a diverse set of important myocardial proteins to produce a final DCM phenotype. Large, publicly available datasets have provided the opportunity to evaluate previously identified DCM-causing mutations, and to examine the population frequency of sequence variants similar to those that have been observed to cause DCM. The frequency of these variants, whether associated with dilated or hypertrophic cardiomyopathy, is greater than estimates of disease prevalence. This mismatch might be explained by one or more of the following possibilities: that the penetrance of DCM-causing mutations is lower than previously thought, that some variants are noncausal, that DCM prevalence is higher than previously estimated, or that other more-complex genomics underlie DCM. Reassessment of our assumptions about the complexity of the genomic and phenomic architecture of DCM is warranted. Much about the genomic basis of DCM remains to be investigated, which will require comprehensive genomic studies in much larger cohorts of rigorously phenotyped probands and family members than previously examined.

Indexed as

MutationAnimalsArrhythmogenic Right Ventricular DysplasiaCardiomyopathy, DilatedCardiomyopathy, Hypertrophic, FamilialGenetic Predisposition to DiseaseGenomicsHeredityHumansPedigreePhenotypeRisk FactorsTerminology as Topic

Identifiers

PMID23900355

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.