ArticleJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences2013
Association of serum uric acid with proteinuria in type 2 diabetic patients.
Article in Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Risk factors for diabetic kidney disease in type 2 diabetes mellitus in Asia: a meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Large-scale cross-ancestry genome-wide meta-analysis of serum urate.Nature communications · 2024Pooled it
- Fenofibrate decreased microalbuminuria in the type 2 diabetes patients with hypertriglyceridemia.Lipids in health and disease · 2020Trial
- Uric acid-lowering and renoprotective effects of topiroxostat, a selective xanthine oxidoreductase inhibitor, in patients with diabetic nephropathy and hyperuricemia: a randomized, double-blind, placebo-controlled, parallel-group study (UPWARD study).Clinical and experimental nephrology · 2018Trial
- Risk factor analysis and predictive model construction and evaluation of fractional uric acid excretion in Chinese inpatients with type 2 diabetes.Scientific reports · 2026Article
- Phosphorus modifies the association between body mass index and uric acid: Results from NHANES 2007-2018.PloS one · 2024Article
- miR-802-5p is a key regulator in diabetic kidney disease.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2023Article
- miRNA-770-5p expression is upregulated in patients with type 2 diabetes and miRNA-770-5p knockdown protects pancreatic β-cell function via targeting BAG5 expression.Experimental and therapeutic medicine · 2021Article
- Pain Perception and Management: Where do We Stand?Current molecular pharmacology · 2021Review
- Associations of serum uric acid level with diabetic retinopathy and albuminuria in patients with type 2 diabetes mellitus.The Journal of international medical research · 2020Article
- Article
- Microalbuminuria and Traditional Serum Biomarkers of Nephropathy among Diabetic Patients at Mbarara Regional Referral Hospital in South Western Uganda.Journal of diabetes research · 2019Article
- Association of serum uric acid with nephropathy in Iranian type 2 diabetic patients.Journal of diabetes and metabolic disorders · 2018Article
- Does Altered Uric Acid Metabolism Contribute to Diabetic Kidney Disease Pathophysiology?Current diabetes reports · 2018Review
- Cancer Phytotherapy: Recent Views on the Role of Antioxidant and Angiogenesis Activities.Journal of evidence-based complementary & alternative medicine · 2017Article
- Medicinal Plants for the Treatment of Acne Vulgaris: A Review of Recent Evidences.Jundishapur journal of microbiology · 2015Review
- Bioassay-Guided Isolation and Identification of Xanthine Oxidase Inhibitory Constituents from the Leaves of Perilla frutescens.Molecules (Basel, Switzerland) · 2015Article
- Fructose and uric acid in diabetic nephropathy.Diabetologia · 2015Review
- Serum Lipids and Proliferative Diabetic Retinopathy and Macular Edema in Persons With Long-term Type 1 Diabetes Mellitus: The Wisconsin Epidemiologic Study of Diabetic Retinopathy.JAMA ophthalmology · 2015Article
- Comment on: Prevention of Renal Damage by Treating Hyperuricemia.International journal of preventive medicine · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVarious findings suggest that uric acid is an inflammatory factor and may have a role in endothelial dysfunction and act as a mediator of diabetic nephropathy. The objective of this study was to evaluate the relationships between serum uric acid level and level of proteinuria in type 2 diabetic (T2D) patients. MATERIALS AND
methodsA cross-sectional analytical study was conducted in 60 patients with T2D without a history of gout. None was treated with allopurinol. Venous blood samples were obtained in fasting state for determinations of serum creatinine, uric acid, and hemoglobin A1c (HbA1c) (reference range 3.8-5.5%); 24-h urine proteinuria was also measured.
resultsMean age of the patients was 57 ± 8.3 years. Mean ± standard error (SE) of serum creatinine was 0.98 ± 0.028 mg/dL, mean ± SE of serum uric acid was 4.5 ± 0.15 mg/dL, and mean ± SE of proteinuria was 388 ± 28.7 mg/day (median = 303.5 mg/day). There was no significant difference in serum uric acid, HbA1c, and creatinine level between males and females (P > 0.05). There was a significant positive association between body mass index (BMI) and serum uric acid levels (r = 0.428, P = 0.001). After adjustment for weight, a significant positive association of serum uric acid with level of proteinuria was seen (r = 0.47, P < 0.001).
conclusionSerum uric acid had a significant positive association with diabetic nephropathy. It might be hypothesized that serum uric acid plays a role in diabetic nephropathy in T2D.
Indexed as
Identifiers
23900353PMC3719225W1501049229What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.