ArticleNature methods2013
Computational approaches to identify functional genetic variants in cancer genomes.
Article in Nature methods, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.
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Who cites it
97 citing papers in PubMed.
- Targeted deep sequencing reveals no definitive evidence for somatic mosaicism in atrial fibrillation.Circulation. Cardiovascular genetics · 2015Trial
- Identification of KRT80 as a Novel Prognostic and Predictive Biomarker of Human Lung Adenocarcinoma via Bioinformatics Approaches.Combinatorial chemistry & high throughput screening · 2025Article
- Biomarker Potential ofInternational journal of medical sciences · 2024Article
- Precision Oncology Comes of Age: Designing Best-in-Class Small Molecules by Integrating Two Decades of Advances in Chemistry, Target Biology, and Data Science.Cancer discovery · 2023Article
- Multi-omics profiling of papillary thyroid microcarcinoma reveals different somatic mutations and a unique transcriptomic signature.Journal of translational medicine · 2023Article
- Identification and validation of differentially expressed genes for targeted therapy in NSCLC using integrated bioinformatics analysis.Frontiers in oncology · 2023Article
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- Genomic profiling and network-level understanding uncover the potential genes and the pathways in hepatocellular carcinoma.Frontiers in genetics · 2022Article
- Mutational signatures representative transcriptomic perturbations in hepatocellular carcinoma.Frontiers in genetics · 2022Article
- PhosVarDeep: deep-learning based prediction of phospho-variants using sequence information.PeerJ · 2022Article
- Review
- The origins and genetic interactions of KRAS mutations are allele- and tissue-specific.Nature communications · 2021Article
- Current cancer driver variant predictors learn to recognize driver genes instead of functional variants.BMC biology · 2021Article
- Computational Prediction of the Pathogenic Status of Cancer-Specific Somatic Variants.Frontiers in genetics · 2021Article
- ActiveDriverDB: Interpreting Genetic Variation in Human and Cancer Genomes Using Post-translational Modification Sites and Signaling Networks (2021 Update).Frontiers in cell and developmental biology · 2021Article
- Prevention of tumor risk associated with the reprogramming of human pluripotent stem cells.Journal of experimental & clinical cancer research : CR · 2020Review
- Somatic synonymous mutations in regulatory elements contribute to the genetic aetiology of melanoma.BMC medical genomics · 2020Article
- Article
- Pathway and network analysis of more than 2500 whole cancer genomes.Nature communications · 2020Article
- Using Transcriptional Signatures to Find Cancer Drivers with LURE.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2020Article
37 more citing papers are in PubMed but not listed here.
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Authors and funding
29 authors.
Funding
Abstract
The International Cancer Genome Consortium (ICGC) aims to catalog genomic abnormalities in tumors from 50 different cancer types. Genome sequencing reveals hundreds to thousands of somatic mutations in each tumor but only a minority of these drive tumor progression. We present the result of discussions within the ICGC on how to address the challenge of identifying mutations that contribute to oncogenesis, tumor maintenance or response to therapy, and recommend computational techniques to annotate somatic variants and predict their impact on cancer phenotype.
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