ArticlePharmacognosy research2013
Protective effects of Vernonia amygdalina against sodium arsenite-induced genotoxicity in rat.
Article in Pharmacognosy research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 14 citations in OpenAlex.
- Molecular insight of arsenic-induced carcinogenesis and its prevention.Naunyn-Schmiedeberg's archives of pharmacology · 2017Review
- Exercise Prevents Memory Impairment Induced by Arsenic Exposure in Mice: Implication of Hippocampal BDNF and CREB.PloS one · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesContamination of the environment with arsenic (As) from both human and natural sources is known as a global problem. This study investigated the chemoprotective potential of Vernonia amygdalina leave extract against sodium arsenite-induced genotoxicity and hepatotoxicity. MATERIALS AND
methodsGenotoxic effects were evaluated in the rat bone marrow using micronuclei. The gamma glutamyl transpeptidase (GGT) and alkaline phosphatase (ALP) activities were assayed in rat serum.
resultsPre-treatment with extract of V. amygdalina at doses 5 mg/kg and 10 mg/kg significantly decreased the frequency of micronucleated polychromatic erythrocytes (PCEs). The GGT and ALP activities were elevated more than fourfold, in the liver of rats treated with sodium arsenite, while it was reduced almost to half when the sodium arsenit-treated rats were fed fresh V. amgdalina leave extracts The phytochemical constituents of V. amygdalina assayed in this study may be responsible for high radical scavenging of the DPPH free radical observed.
conclusionThe present results indicate that V. amygdalina extract is capable of suppressing the chromosomal aberration induced by sodium arsenite in rat. Thus, V. amygdalina may be a potent chemoprotective agent against the toxicity of sodium arsenite in rats.
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