Evidence map›Paper›PMID 23900020›Full record

ArticleThe Journal of investigative dermatology2014

Dynamic analysis of histamine-mediated attenuation of acetylcholine-induced sweating via GSK3β activation.

Saki Matsui, Hiroyuki Murota, Aya Takahashi, Lingli Yang, Jeong-Beom Lee, Kouta Omiya, Masato Ohmi, Junichi Kikuta, Masaru Ishii, Ichiro Katayama

Abstract read
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In one paragraph

Article in The Journal of investigative dermatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 42 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Atopic Dermatitis: Identification and Management of Complicating Factors.International journal of molecular sciences · 2020
    Review
  5. Article
  6. Review
  7. [Hyperhidrosis-aetiopathogenesis, diagnosis, clinical symptoms and treatment].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2018
    Article
  8. Review
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Saki MatsuiDepartment of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.
Hiroyuki MurotaDepartment of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan. Electronic address: h-murota@derma.med.osaka-u.ac.jp.
Aya TakahashiDepartment of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.
Lingli YangDepartment of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.
Jeong-Beom LeeDepartment of Physiology, College of Medicine, Soonchunhyang University, Chenan, Republic of Korea.
Kouta OmiyaCourse of Health Science, Graduate School of Medicine, Osaka University, Osaka, Japan.
Masato OhmiCourse of Health Science, Graduate School of Medicine, Osaka University, Osaka, Japan.
Junichi KikutaLaboratory of Cellular Dynamics, WPI-Immunology Frontier Research Center, Osaka University, Osaka, Japan.
Masaru IshiiLaboratory of Cellular Dynamics, WPI-Immunology Frontier Research Center, Osaka University, Osaka, Japan.
Ichiro KatayamaDepartment of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.
Osaka University · JPOsaka Health Science University · JPSoonchunhyang University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sweating has been associated with the exacerbation of atopic dermatitis (AD) in diverse ways. Acetylcholine (ACh)-mediated sweating is known to be attenuated in AD, but its cause remains obscure. To address this issue, the impact of histamine on ACh-induced sweating was evaluated. Sweating was measured by counting the number of active sweat pores by the starch-iodine reaction and dynamic optical coherence tomography; sweat was visualized using two-photon excitation fluorescence microscopy in mice and the quantitative sudomotor axon reflex test in humans. Both histamine receptor antagonists and H1 receptor (H1R)-knockout (KO) mice were used to determine methodological specificity. Histamine demonstrably inhibited ACh-induced sweating in both mice and humans via H1R-mediated signaling. In sweat glands, ACh inactivated glycogen synthase kinase 3β (GSK3β), a kinase involved in endocytosis and secretion, whereas simultaneous stimulation with histamine activated GSK3β. Results of two-photon excitation fluorescence microscopy confirmed the dynamic motion of sweat and sweat glands after ACh treatment, showing that simultaneous stimulation with histamine altered their dynamic properties. These results indicate that histamine inhibits sweat gland secretions by blocking ACh-induced inactivation of GSK3β. Histamine-mediated hypohidrosis might be involved in the mechanism of abnormal skin dryness in patients with AD.

Indexed as

AcetylcholineAnimalsAxonsCellular MicroenvironmentDermatitis, AtopicFemaleGlycogen Synthase Kinase 3Glycogen Synthase Kinase 3 betaHealthy VolunteersHistamineHistamine H1 AntagonistsHumansHypohidrosisMiceMice, Inbred C57BLMice, KnockoutAcetylcholineGlycogen Synthase Kinase 3Glycogen Synthase Kinase 3 betaGSK3B protein, humanGsk3b protein, mouseHistamineHistamine H1 AntagonistsReceptors, Histamine H1

Identifiers

PMID23900020
OpenAlexW2034087063

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.