Evidence map›Paper›PMID 23899964›Full record

ArticleThe Pediatric infectious disease journal2013

Human milk galectin-3 binding protein and breast-feeding-associated HIV transmission.

Christina S Chan, Hae-Young Kim, Chloe Autran, Jae H Kim, Moses Sinkala, Chipepo Kankasa, Mwiya Mwiya, Donald M Thea, Grace M Aldrovandi, Louise Kuhn and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Pediatric infectious disease journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Galectinology of Equine Pregnancy.Animals : an open access journal from MDPI · 2022
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Christina S ChanFrom the *Divisions of Neonatology and Pediatric Gastroenterology and Nutrition, Department of Pediatrics, University of California, San Diego, CA; †Gertrude H. Sergievsky Center, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY; ‡Lusaka District Health Management Team; §University Teaching Hospital, University of Zambia, Lusaka, Zambia; ¶Center for International Health & Development, Boston University School of Public Health, Boston, MA; and ‖Department of Pediatrics, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA.
Hae-Young Kim
Chloe Autran
Jae H Kim
Moses Sinkala
Chipepo Kankasa
Mwiya Mwiya
Donald M Thea
Grace M Aldrovandi
Louise Kuhn
Lars Bode
University of California, San Diego · USBoston University · USColumbia University · USUniversity of Lusaka · ZM

Funding

VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Maile Ann Young Karris · 1994 to 2026
$78.4M
LC - IMPAACT Leadership GroupUM1AI106716 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Grace M Aldrovandi · 2014 to 2026
$47.2M
Short Exclusive Breastfeeding to Reduce Postnatal Transmission of HIVR01HD039611 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI THEA, DONALD M · 2000 to 2006
$8.0M
Pathogenesis of Mother to Child Transmission of HIVR01HD040777 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ALDROVANDI, GRACE M · 2002 to 2011
$4.4M
Safer Weaning Practices for HIV-infected womenR01HD057617 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUHN, LOUISE · 2007 to 2011
$2.0M
Oral Transmission of HIV through BreastfeedingR01DE021238 · NIDCR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ALDROVANDI, GRACE M, KUHN, LOUISE · 2010 to 2013
$1.7M
Fusing Glycobiology and Nutritional Sciences to Prevent Necrotizing EnterocolitisR00DK078668 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BODE, LARS · 2009 to 2011
$747k
NIAID NIH HHS P30 AI036214NIAID NIH HHS UM1 AI106716NICHD NIH HHS HD39611NICHD NIH HHS HD40777NICHD NIH HHS HD57617NICHD NIH HHS R01 HD039611NICHD NIH HHS R01 HD040777NICHD NIH HHS R01 HD057617NIDCR NIH HHS DE021238NIDCR NIH HHS R01 DE021238NIDDK NIH HHS R00 DK078668
6 · The paper itself

Abstract

Analysis of milk from 247 HIV-infected Zambian mothers showed that galectin-3 binding protein concentrations were significantly higher among HIV-infected mothers who transmitted HIV through breast-feeding (6.51 ± 2.12 μg/mL) than among nontransmitters but were also correlated with higher milk and plasma HIV RNA copies/mL and lower CD4+ cell counts. The association between galectin-3 binding protein and postnatal transmission was attenuated after adjustment for milk and plasma HIV load and CD4+ cell counts. This suggests that although milk galectin-3 binding protein is a marker of advanced maternal disease, it does not independently modify transmission risk.

Indexed as

Breast FeedingInfectious Disease Transmission, VerticalAntigens, NeoplasmBiomarkers, TumorCarrier ProteinsCase-Control StudiesExtracellular Matrix ProteinsFemaleGlycoproteinsHIV InfectionsHumansMilk, HumanRisk FactorsViral LoadZambiaAntigens, NeoplasmBiomarkers, TumorCarrier ProteinsExtracellular Matrix ProteinsGlycoproteinsLGALS3BP protein, human

Identifiers

PMID23899964
PMCPMC3907473
OpenAlexW2076246379

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.