Trial reportMedicine and science in sports and exercise2014
Genetic modifiers of cardiorespiratory fitness response to lifestyle intervention.
Trial report in Medicine and science in sports and exercise, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- The Association of Cardiorespiratory Fitness on Memory Function: Systematic Review.Medicina (Kaunas, Lithuania) · 2019Pooled it
- Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading States.Cell reports · 2020Trial
- Physical Activity, Cardiorespiratory Fitness, and the Obesity Paradox with Consideration for Racial and/or Ethnic Differences: A Broad Review and Call to Action.Reviews in cardiovascular medicine · 2024Review
- Physical Fitness and Cardiovascular Risk Factors in Novel Diabetes Subgroups.The Journal of clinical endocrinology and metabolism · 2022Article
- Neurophysiological correlates of interference control and response inhibition processes in children and adolescents engaging in open- and closed-skill sports.Journal of sport and health science · 2022Article
- Mean arterial pressure, fitness, and executive function in middle age and older adults.Cerebral circulation - cognition and behavior · 2022Article
- Isotemporal substitution of sedentary behavior for physical activity on cardiorespiratory fitness in children and adolescents.Medicine · 2020Observational
- Exercise capacity of vegan, lacto-ovo-vegetarian and omnivorous recreational runners.Journal of the International Society of Sports Nutrition · 2019Article
- Cardiorespiratory Fitness Predicts Greater Vagal Autonomic Activity in Drug Users Under Stress.Substance abuse : research and treatment · 2019Article
- Cardiorespiratory fitness and the metabolic syndrome: Roles of inflammation and abdominal obesity.PloS one · 2018Article
- Genetic risk variants for metabolic traits in Arab populations.Scientific reports · 2017Article
- A Practical and Time-Efficient High-Intensity Interval Training Program Modifies Cardio-Metabolic Risk Factors in Adults with Risk Factors for Type II Diabetes.Frontiers in endocrinology · 2017Article
- A reverse genetics cell-based evaluation of genes linked to healthy human tissue age.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Vascular Health and Genetic Risk Affect Mild Cognitive Impairment Status and 4-Year Stability: Evidence From the Victoria Longitudinal Study.The journals of gerontology. Series B, Psychological sciences and social sciences · 2016Article
- Review
- What Is Fitness Training? Definitions and Implications: A Systematic Review Article.Iranian journal of public health · 2015Review
- Physical Activity Is Linked to Greater Moment-To-Moment Variability in Spontaneous Brain Activity in Older Adults.PloS one · 2015Article
- Physical activity and cardiorespiratory fitness are beneficial for white matter in low-fit older adults.PloS one · 2014Article
- Social, behavioral and biological correlates of cardiorespiratory fitness according to sex, nutritional status and maturity status among adolescents. A cross-sectional study.Sao Paulo medical journal = Revista paulista de medicinaArticle
Corrections and comments
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Authors and funding
15 authors at 11 institutions in 3 countries.
Funding
Abstract
purposeNumerous prospective studies indicate that improved cardiorespiratory fitness reduces type 2 diabetes risk and delays disease progression. We hypothesized that genetic variants modify fitness response to an intensive lifestyle intervention (ILI) in the Action for Health in Diabetes (Look AHEAD) randomized clinical trial, aimed to detect whether ILI will reduce cardiovascular events in overweight/obese subjects with type 2 diabetes compared with a standard of care.
methodsPolymorphisms in established fitness genes and in all loci assayed on the Illumina CARe iSelect chip were examined as predictors of change in MET level, estimated using a treadmill test, in response to a 1-yr intervention in 3899 participants.
resultsWe identified a significant signal in previously reported fitness-related gene RUNX1 that was associated with 1-yr METs response in ILI (0.19 ± 0.04 MET less improvement per minor allele copy; P = 1.9 × 10(-5)) and genotype-intervention interaction (P = 4.8 × 10(-3)). In the chipwide analysis, FKBP7 rs17225700 showed a significant association with ILI response among subjects not receiving beta-blocker medications (0.47 ± 0.09 METs less improvement; P = 5.3 × 10(-5)) and genotype-treatment interaction (P = 5.3 × 10(-7)). The Gene Relationships Among Implicated Loci pathway-based analysis identified connections between associated genes, including those influencing vascular tone, muscle contraction, cardiac energy substrate dynamics, and muscle protein synthesis.
conclusionsThis is the first study to identify genetic variants associated with fitness responses to a randomized lifestyle intervention in overweight/obese diabetic individuals. RUNX1 and FKBP7, involved in erythropoesis and muscle protein synthesis, respectively, are related to change in cardiorespiratory fitness in response to exercise.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.