ReviewOrganogenesis
High throughput screening to investigate the interaction of stem cells with their extracellular microenvironment.
Review in Organogenesis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Structural Control of Nanofibers According to Electrospinning Process Conditions and Their Applications.Micromachines · 2023Review
- A paradigm for high-throughput screening of cell-selective surfaces coupling orthogonal gradients and machine learning-based cell recognition.Bioactive materials · 2023Article
- Morphodynamical cell state description via live-cell imaging trajectory embedding.Communications biology · 2023Article
- An Automated High-Throughput Screening (HTS) Spotter for 3D Tumor Spheroid Formation.International journal of molecular sciences · 2023Article
- Extracellular matrix and biomimetic engineering microenvironment for neuronal differentiation.Neural regeneration research · 2020Review
- Solid-phase combinatorial synthesis using microarrays of microcompartments with light-induced on-chip cell screening.Materials today. Bio · 2019Article
- Evaluation of the topographical influence on the cellular behavior of human umbilical vein endothelial cells.Advanced biosystems · 2018Article
- Living Cell Microarrays: An Overview of Concepts.Microarrays (Basel, Switzerland) · 2016Review
- A synthetic hydrogel for the high-throughput study of cell-ECM interactions.Nature communications · 2015Article
- Matrilin-2 is a widely distributed extracellular matrix protein and a potential biomarker in the early stage of osteoarthritis in articular cartilage.BioMed research international · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stem cells in vivo are housed within a functional microenvironment termed the "stem cell niche." As the niche components can modulate stem cell behaviors like proliferation, migration and differentiation, evaluating these components would be important to determine the most optimal platform for their maintenance or differentiation. In this review, we have discussed methods and technologies that have aided in the development of high throughput screening assays for stem cell research, including enabling technologies such as the well-established multiwell/microwell plates and robotic spotting, and emerging technologies like microfluidics, micro-contact printing and lithography. We also discuss the studies that utilized high throughput screening platform to investigate stem cell response to extracellular matrix, topography, biomaterials and stiffness gradients in the stem cell niche. The combination of the aforementioned techniques could lay the foundation for new perspectives in further development of high throughput technology and stem cell research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.