Evidence map›Paper›PMID 23899493›Full record

ArticlePublic health genomics2013

Who gets genomic testing for breast cancer recurrence risk?

J T DeFrank, T Salz, K Reeder-Hayes, N T Brewer

Open access · bronzeAbstract read
In one paragraph

Article in Public health genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Disparities in OncotypeDx Testing and Subsequent Chemotherapy Receipt by Geography and Socioeconomic Status.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Racial Differences in 21-Gene Recurrence Scores Among Patients With Hormone Receptor-Positive, Node-Negative Breast Cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2018
    Article
  10. 21-Gene recurrence score testing among Medicare beneficiaries with breast cancer in 2010-2013.Genetics in medicine : official journal of the American College of Medical Genetics · 2017
    Article
  11. Article
  12. Implementation of the 21-gene recurrence score test in the United States in 2011.Genetics in medicine : official journal of the American College of Medical Genetics · 2016
    Article
  13. Racial Variation in the Uptake of Oncotype DX Testing for Early-Stage Breast Cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2016
    Article
  14. ONCOLOGISTS' BARRIERS AND FACILITATORS FOR ONCOTYPE DX USE: QUALITATIVE STUDY.International journal of technology assessment in health care · 2016
    Article
  15. Article
  16. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

J T DeFrankDepartment of Health Behavior, UNC Gillings School of Global Public Health, Chapel Hill, N.C., USA.
T Salz
K Reeder-Hayes
N T Brewer
UNC Lineberger Comprehensive Cancer CenterMemorial Sloan Kettering Cancer Center · US

Funding

Tissue Procurement & PathologyP50CA058223 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CHARLES M PEROU · 1992 to 2026
$59.3M
Cancer Training GrantR25CA116339 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BASCH, ETHAN M., REEVE, BRYCE B · 2008 to 2017
$4.0M
Cancer Care Quality Training ProgramT32CA116339 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ETHAN M. BASCH, Stephanie Brooke Wheeler · 2018 to 2026
$3.0M
NCI NIH HHS P50 CA058223NCI NIH HHS R25 CA116339NCI NIH HHS T32 CA116339
6 · The paper itself

Abstract

BACKGROUND/

aimsOur study examined whether patient characteristics, beliefs and decision-making styles were associated with uptake of genomic testing for breast cancer recurrence risk.

methodsParticipants were 132 early-stage breast cancer patients eligible for the Oncotype DX genomic test. We interviewed patients in 2009-2010 and obtained information from medical charts.

resultsHalf of the women eligible for genomic testing for breast cancer recurrence risk received it. The most common reason for not getting the test was that women's physicians did not offer it (80%). Test recipients were more likely to be unsure about receiving chemotherapy treatment compared to women who did not receive the test (p < 0.05). Women who received the test had less advanced disease pathologies, recalled a lower objective recurrence risk, perceived lower recurrence risk, and were slightly younger (all p < 0.05). Most women who described their decision-making style as active received the test (75%), whereas few women who described their style as passive received the test (12%) (p < 0.01).

conclusionIn the university clinic we studied, genomic testing appeared to be more common among patients who may benefit most from the information provided by results, but confirmation in larger studies is needed.

Indexed as

Decision MakingAgedAge FactorsBreast NeoplasmsFemaleGenetic TestingGenome, HumanGenomicsHumansMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingRisk

Identifiers

PMID23899493
PMCPMC3884690
OpenAlexW2065664107

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.