Trial reportRespiratory research2013
Factors associated with change in exacerbation frequency in COPD.
Trial report in Respiratory research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00292552 (A Multicentre 3 Year Longitudinal Prospective Study to Identify Novel Endpoints and Compare These With Forced Expiratory Volume in 1 Second), which is not on this map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multicentre 3 Year Longitudinal Prospective Study to Identify Novel Endpoints and Compare These With Forced Expiratory Volume in 1 Second (FEV1) for Their Ability to Measure and Predict COPD Severity and Its Progression Over Time
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Burden of Disease in Patients with Mild or Mild-to-Moderate Chronic Obstructive Pulmonary Disease (Global Initiative for Chronic Obstructive Lung Disease Group A or B): A Systematic Literature Review.International journal of chronic obstructive pulmonary disease · 2023Pooled it
- A Double-Blind, Randomized, Placebo-controlled Trial of Long-Term Doxycycline Therapy on Exacerbation Rate in Patients with Stable Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2023Trial
- Findings from a pilot randomised trial of a social network self-management intervention in COPD.BMC pulmonary medicine · 2020Trial
- Determinants of exacerbation risk in patients with COPD in the TIOSPIR study.International journal of chronic obstructive pulmonary disease · 2017Trial
- Tiotropium and Salmeterol in COPD Patients at Risk of Exacerbations: A Post Hoc Analysis from POET-COPD(®).Advances in therapy · 2015Trial
- Factors associated with change in exacerbation frequency in COPD.Respiratory research · 2013Trial
- Transitions to and reversion from a persistent frequent-exacerbator state in COPD.ERJ open research · 2026Article
- Krebs von den Lungen-6 as a potent indicator of the frequency of chronic obstructive pulmonary disease exacerbation.The Journal of international medical research · 2025Article
- Article
- Towards precision in defining COPD exacerbations.Breathe (Sheffield, England) · 2021Review
- COPD Clinical Control: predictors and long-term follow-up of the CHAIN cohort.Respiratory research · 2021Observational
- Classification of Exacerbation Frequency in the COPDGene Cohort Using Deep Learning With Deep Belief Networks.IEEE journal of biomedical and health informatics · 2020Article
- Genetic variants in IL17A and serum levels of IL-17A are associated with COPD related to tobacco smoking and biomass burning.Scientific reports · 2020Article
- Identification of Patient Profiles with High Risk of Hospital Re-Admissions for Acute COPD Exacerbations (AECOPD) in France Using a Machine Learning Model.International journal of chronic obstructive pulmonary disease · 2020Article
- Management of the COPD Patient with Comorbidities: An Experts Recommendation Document.International journal of chronic obstructive pulmonary disease · 2020Article
- Modelling the Cost-Effectiveness of Indacaterol/Glycopyrronium versus Salmeterol/Fluticasone Using a Novel Markov Exacerbation-Based Approach.International journal of chronic obstructive pulmonary disease · 2020Article
- Haplotype inInternational journal of molecular sciences · 2019Article
- The European COPD audit : Adherence to guidelines, readmission risk and hospital care for acute exacerbations in Austria.Wiener klinische Wochenschrift · 2019Article
- Patient Preferences for Endobronchial Valve Treatment of Severe Emphysema.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2018Article
- At the Root: Defining and Halting Progression of Early Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundPatients with chronic obstructive pulmonary disease (COPD) can be categorized as having frequent (FE) or infrequent (IE) exacerbations depending on whether they respectively experience two or more, or one or zero exacerbations per year. Although most patients do not change category from year to year, some will, and the factors associated with this behaviour have not been examined.
methods1832 patients completing two year follow-up in the Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE) study were examined at baseline and then yearly. Exacerbations were defined by health care utilisation. Patient characteristics compared between those patients who did or did not change exacerbation category from year 1 to year 2.
findingsBetween years 1 and 2, 221 patients (17%) changed from IE to FE and 210 patients (39%) from FE to IE. More severe disease was associated with changing from IE to FE and less severe disease from FE to IE. Over the preceding year, small falls in FEV1 and 6-minute walking distance were associated with changing from IE to FE, and small falls in platelet count associated with changing from FE to IE.
conclusionNo parameter clearly predicts an imminent change in exacerbation frequency category.
trial registrationSCO104960, clinicaltrials.gov identifier NCT00292552.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.