ArticleMolecular microbiology2013
Sigma factor RpoN (σ54) regulates pilE transcription in commensal Neisseria elongata.
Article in Molecular microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Type IV pilin regulation: a transcriptional overview.Critical reviews in microbiology · 2026Review
- Two-component systems as potential therapeutic targets inAnnals of medicine · 2025Review
- More than a feeling: microscopy approaches to understanding surface-sensing mechanisms.Journal of bacteriology · 2020Review
- Contribution of σJournal of bacteriology · 2019Article
- Commensal Neisseria Kill Neisseria gonorrhoeae through a DNA-Dependent Mechanism.Cell host & microbe · 2019Article
- RpoN and the Nps and Npa two-component regulatory system control pilE transcription in commensal Neisseria.MicrobiologyOpen · 2019Article
- Sigma factor RpoN employs a dual transcriptional regulation for controlling twitching motility and biofilm formation in Lysobacter enzymogenes OH11.Current genetics · 2018Article
- Article
- Genome-wide screen identifies host colonization determinants in a bacterial gut symbiont.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Neisseria cinerea isolates can adhere to human epithelial cells by type IV pilus-independent mechanisms.Microbiology (Reading, England) · 2016Article
- Neisseria elongata subsp elongata infective endocarditis following endurance exercise.BMJ case reports · 2015Article
- Characterization of a novel antisense RNA in the major pilin locus of Neisseria meningitidis influencing antigenic variation.Journal of bacteriology · 2015Article
- rpoN1, but not rpoN2, is required for twitching motility, natural competence, growth on nitrate, and virulence of Ralstonia solanacearum.Frontiers in microbiology · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
Human-adapted Neisseria includes two pathogens, Neisseria gonorrhoeae and Neisseria meningitidis, and at least 13 species of commensals that colonize many of the same niches as the pathogens. The Type IV pilus plays an important role in the biology of pathogenic Neisseria. In these species, Sigma factor RpoD (σ(70)), Integration Host Factor, and repressors RegF and CrgA regulate transcription of pilE, the gene encoding the pilus structural subunit. The Type IV pilus is also a strictly conserved trait in commensal Neisseria. We present evidence that a different mechanism regulates pilE transcription in commensals. Using Neisseria elongata as a model, we show that Sigma factor RpoN (σ(54)), Integration Host Factor, and an activator we name Npa regulate pilE transcription. Taken in context with previous reports, our findings indicate pilE regulation switched from an RpoN- to an RpoD-dependent mechanism as pathogenic Neisseria diverged from commensals during evolution. Our findings have implications for the timing of Tfp expression and Tfp-mediated host cell interactions in these two groups of bacteria.
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