ArticleEnvironmental science & technology2013
The good, the bad, and the toxic: approaching hormesis in Daphnia magna exposed to an energetic compound.
Article in Environmental science & technology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 58 citations in OpenAlex.
- The Chronic Toxicity of Endocrine-Disrupting Chemical toInternational journal of molecular sciences · 2024Article
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- Machine Learning Models for Identification and Prediction of Toxic Organic Compounds UsingLife (Basel, Switzerland) · 2022Article
- Characteristics of toxin production and release in Microcystis aeruginosa exposed to three tetracycline antibiotics.Environmental science and pollution research international · 2020Article
- Different as night and day: Behavioural and life history responses to varied photoperiods in Daphnia magna.Molecular ecology · 2019Article
- Short-term exposure to tricyclic antidepressants delays righting time in marine and freshwater snails with evidence for low-dose stimulation of righting speed by imipramine.Environmental science and pollution research international · 2019Article
- Growth and Lipidomic Responses of Juvenile Pacific White ShrimpFrontiers in physiology · 2019Article
- Metabolomics Discovers Early-Response Metabolic Biomarkers that Can Predict Chronic Reproductive Fitness in IndividualMetabolites · 2018Article
- Differential sensitivity to the antifouling chemical medetomidine between wood frog and American toad tadpoles with evidence for low-dose stimulation and high-dose inhibition of metamorphosis.Environmental science and pollution research international · 2018Article
- Differential gene transcription across the life cycle in Daphnia magna using a new all genome custom-made microarray.BMC genomics · 2018Article
- Conceptualizing ecosystem tipping points within a physiological framework.Ecology and evolution · 2017Article
- Article
- Daphnia magna's sense of competition: intra-specific interactions (ISI) alter life history strategies and increase metals toxicity.Ecotoxicology (London, England) · 2016Article
- Systems toxicology identifies mechanistic impacts of 2-amino-4,6-dinitrotoluene (2A-DNT) exposure in Northern Bobwhite.BMC genomics · 2015Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
A hormetic response is characterized by an opposite effect in small and large doses of chemical exposure, often resulting in seemingly beneficial effects at low doses. Here, we examined the potential mechanisms underlying the hormetic response of Daphnia magna to the energetic trinitrotoluene (TNT). Daphnia magna were exposed to TNT for 21 days, and a significant increase in adult length and number of neonates was identified at low concentrations (0.002-0.22 mg/L TNT), while toxic effects were identified at high concentrations (0.97 mg/L TNT and above). Microarray analysis of D. magna exposed to 0.004, 0.12, and 1.85 mg/L TNT identified effects on lipid metabolism as a potential mechanism underlying hormetic effects. Lipidomic analysis of exposed D. magna supported the hypothesis that TNT exposure affected lipid and fatty acid metabolism, showing that hormetic effects could be related to changes in polyunsaturated fatty acids known to be involved in Daphnia growth and reproduction. Our results show that Daphnia exposed to low levels of TNT presented hormetic growth and reproduction enhancement, while higher TNT concentrations had an opposite effect. Our results also show how a systems approach can help elucidate potential mechanisms of action and adverse outcomes.
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