Trial reportBMC psychiatry2013
Integrated treatment vs. treatment-as-usual for recent onset schizophrenia; 12 year follow-up on a randomized controlled trial.
Trial report in BMC psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00184509 (Continued Early Intervention for Recent-onset Schizophrenia. A Randomized Controlled Study.), which is not on this map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Continued Early Intervention for Recent-onset Schizophrenia. A Randomized Controlled Study.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Specialised early intervention teams (extended time) for recent-onset psychosis.The Cochrane database of systematic reviews · 2020Pooled it
- Specialised early intervention teams for recent-onset psychosis.The Cochrane database of systematic reviews · 2020Pooled it
- Comparison of Early Intervention Services vs Treatment as Usual for Early-Phase Psychosis: A Systematic Review, Meta-analysis, and Meta-regression.JAMA psychiatry · 2018Pooled it
- Outcomes During and After Early Intervention Services for First-Episode Psychosis: Results Over 5 Years From the RAISE-ETP Site-Randomized Trial.Schizophrenia bulletin · 2022Trial
- Predictors of long term use of psychiatric services of patients with recent-onset schizophrenia: 12 years follow-up.BMC psychiatry · 2017Trial
- Five years of specialised early intervention versus two years of specialised early intervention followed by three years of standard treatment for patients with a first episode psychosis: randomised, superiority, parallel group trial in Denmark (OPUS II).BMJ (Clinical research ed.) · 2017Trial
- The RAISE early treatment program for first-episode psychosis: background, rationale, and study design.The Journal of clinical psychiatry · 2015Trial
- Do early intervention services for psychosis maintain their effects after transition to usual/modular care? A systematic review and meta-analysis.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026Article
- The EnTRy Program: Expanding Coordinated Specialty Care Beyond Early Psychosis.Community mental health journal · 2025Article
- Implementation of an Adapted Fidelity Scale for Pennsylvania Coordinated Specialty Care Programs for First Episode Psychosis.Prevention science : the official journal of the Society for Prevention Research · 2024Article
- Prevention and early intervention in youth mental health: is it time for a multidisciplinary and trans-diagnostic model for care?International journal of mental health systems · 2020Review
- Psychosocial Interventions to Reduce Compulsory Psychiatric Admissions: A Rapid Evidence Synthesis.EClinicalMedicine · 2019Article
- Effectiveness and cost-effectiveness of an integrated care program for schizophrenia: an analysis of routine data.European archives of psychiatry and clinical neuroscience · 2018Article
- Transforming the Treatment of Schizophrenia in the United States: The RAISE Initiative.Annual review of clinical psychology · 2018Article
- Improving outcomes of first-episode psychosis: an overview.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2017Article
- The effect of duration of untreated psychosis and treatment delay on the outcomes of prolonged early intervention in psychotic disorders.NPJ schizophrenia · 2017Article
- The NAVIGATE Program for First-Episode Psychosis: Rationale, Overview, and Description of Psychosocial Components.Psychiatric services (Washington, D.C.) · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study is to compare the 12-year follow-up effects on in- and outpatient services of 2 years of integrated treatment for recent-onset schizophrenia versus treatment as usual in a randomized controlled trial.
methods50 patients aged 18-35 years were randomized to Integrated Treatment (IT) (N = 30) or Treatment-as-Usual (TAU) (N = 20) for two years. TAU comprised optimal pharmacotherapy and outreach assertive treatment, while IT also included cognitive-behavioural family treatment, skills training, strategies for residual psychotic and non-psychotic problems and home-based crisis management.
resultsThere were no differences in number of days in hospital, time to readmission, number of admittances to psychiatric wards, number of involuntarily psychiatric admissions or number of outpatient contacts over a period of 12 years following the initial 2-year treatment trial. Fewer patients in the IT group were, however, involuntary admitted to hospital in the period.
conclusionsThe intensive two-year psychosocial intervention seemed to have little long-term effects on use of in- and outpatient services.
trial registrationCurrent Controlled Trials: NCT00184509.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.