ArticleFrontiers in neuroscience2013
A paradoxical association of an oxytocin receptor gene polymorphism: early-life adversity and vulnerability to depression.
Article in Frontiers in neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 3 syntheses or guidelines pooled it, 162 citations in OpenAlex.
- Oxytocin dysfunction in severe mental illnesses following adverse childhood experiences: a systematic review.BMC psychiatry · 2026Pooled it
- FMRFamide-like peptides expand the behavioral repertoire of a densely connected nervous system.Proceedings of the National Academy of Sciences of the United States of America · 2017Pooled it
- Association of Oxytocin Receptor Gene (OXTR) rs53576 Polymorphism with Sociality: A Meta-Analysis.PloS one · 2015Pooled it
- Oxytocin Deficiency in Childhood and Adolescence: Clinical Features, Diagnostic Challenges and Therapeutic Perspectives.Current issues in molecular biology · 2025Review
- Pleiotropic effects of oxytocin receptor polymorphisms: influencing striatocortical connectivity in bipolar disorder.International journal of bipolar disorders · 2025Article
- The Role of Oxytocin and Vasopressin in People with Borderline Personality Disorder: A Closer Look at Adolescents.International journal of molecular sciences · 2024Review
- Gene-Environment Interactions in Irrational Beliefs: The Roles of Childhood Adversity and Multiple Candidate Genes.International journal of molecular sciences · 2024Article
- CD38 genetic variation is associated with increased personal distress to an emotional stimulus.Scientific reports · 2024Article
- Intranasal Oxytocin and Pain Reduction: Testing a Social Cognitive Mediation Model.Brain sciences · 2023Article
- The interaction of the oxytocin receptor gene and child abuse subtypes on social cognition in euthymic patients with bipolar disorder type I.Frontiers in psychiatry · 2023Article
- The neuroanatomy of social trust predicts depression vulnerability.Scientific reports · 2022Article
- The Interaction Effect of Parental Rejection and Oxytocin Receptor Gene Polymorphism on Depression: A Cross-Cultural Study in Non-Clinical Samples.International journal of environmental research and public health · 2022Article
- Exploring the Structure and Interrelations of Time-Stable Psychological Resilience, Psychological Vulnerability, and Social Cohesion.Frontiers in psychiatry · 2022Article
- Roles of Oxytocin in Stress Responses, Allostasis and Resilience.International journal of molecular sciences · 2021Review
- Identification of oxytocin receptor activating chemical components from traditional Japanese medicines.Journal of food and drug analysis · 2021Article
- Transdiagnostic biomarker approaches to mental health disorders: Consideration of symptom complexity, comorbidity and context.Brain, behavior, & immunity - health · 2021Article
- An interaction between early threat exposure and the oxytocin receptor in females: Disorder-specific versus general risk for psychopathology and social-emotional mediators.Development and psychopathology · 2021Article
- Article
- Review of eating disorders and oxytocin receptor polymorphisms.Journal of eating disorders · 2021Review
- Oxytocin receptor variant rs53576 genotype is associated with dysphoric arousal symptoms of DSM-5 posttraumatic stress disorder in Chinese earthquake survivors.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2021Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several prosocial behaviors may be influenced by the hormone oxytocin. In line with this perspective, the oxytocin receptor (OXTR) gene single nucleotide polymorphism (SNP), rs53576, has been associated with a broad range of social behaviors. In this regard, the G allele of the OXTR SNP has been accompanied by beneficial attributes such as increased empathy, optimism, and trust. In the current study among university students (N = 288), it was shown that early-life maltreatment was associated with depressive symptoms, and that the OXTR genotype moderated this relationship, such that under high levels of childhood maltreatment, only individuals with GG/GA genotype demonstrated increased depressive symptomatology compared to those with the AA genotype. In addition, the role of distrust in mediating the relation between childhood maltreatment and depression seemed to be more important among G allele carriers compared to individuals with the AA genotype. Thus, a breach in trust (i.e., in the case of early-life abuse or neglect) may have a more deleterious effect among G carriers, who have been characterized as more prosocial and attuned to social cues. The data suggested that G carriers of the OXTR might favor social sensitivity and thus might have been more vulnerable to the effects of early-life adversity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.