ArticleClinical ophthalmology (Auckland, N.Z.)2013
Intervention with vitamins in patients with nonproliferative diabetic retinopathy: a pilot study.
Article in Clinical ophthalmology (Auckland, N.Z.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Do Nutrients and Nutraceuticals Play a Role in Diabetic Retinopathy? A Systematic Review.Nutrients · 2022Pooled it
- Association between dietary folic acid intake and diabetic retinopathy among patients with diabetes: An analysis of 2005-2008 NHANES data.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Article
- B Vitamins and Ocular Health.Clinical ophthalmology (Auckland, N.Z.) · 2026Review
- The Role of Diet and Oral Supplementation for the Management of Diabetic Retinopathy and Diabetic Macular Edema: A Narrative Review.BioMed research international · 2025Review
- Article
- A Mediterranean Diet May Be Protective in the Development of Diabetic Retinopathy.International journal of molecular sciences · 2023Review
- The role of dietary antioxidants in type 2 diabetes and neurodegenerative disorders: An assessment of the benefit profile.Heliyon · 2023Review
- The Roles of Vitamins in Diabetic Retinopathy: A Narrative Review.Journal of clinical medicine · 2022Review
- Biochemical mechanism underlying the pathogenesis of diabetic retinopathy and other diabetic complications in humans: the methanol-formaldehyde-formic acid hypothesis.Acta biochimica et biophysica Sinica · 2022Article
- Unravelling theMolecules (Basel, Switzerland) · 2022Article
- Effects of Ocufolin on retinal microvasculature in patients with mild non-proliferative diabetic retinopathy carrying polymorphisms of the MTHFR gene.BMJ open diabetes research & care · 2021Article
- Nutritional and medical food therapies for diabetic retinopathy.Eye and vision (London, England) · 2020Review
- Folic Acid Has a Protective Effect on Retinal Vascular Endothelial Cells against High Glucose.Molecules (Basel, Switzerland) · 2018Article
- Nutrition for diabetic retinopathy: plummeting the inevitable threat of diabetic vision loss.European journal of nutrition · 2017Review
- Concentrations of Water-Soluble Vitamins in Blood and Urinary Excretion in Patients with Diabetes Mellitus.Nutrition and metabolic insights · 2016Article
- Metanx and early stages of diabetic retinopathy.Investigative ophthalmology & visual science · 2015Article
- Vitamins and type 2 diabetes mellitus.Endocrine, metabolic & immune disorders drug targets · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe purpose of this study was to determine whether a combination of vitamins B6, B9, and B12 is an effective intervention for reducing the signs and symptoms of nonproliferative diabetic retinopathy.
methodsTen subjects with type 2 diabetes mellitus (n = 20 eyes) with clinically diagnosed mild to moderate nonproliferative diabetic retinopathy were recruited from a private practice ophthalmology clinic for this open-label, uncontrolled, prospective six-month study. Metanx® vitamin tablets (containing 3 mg L-methylfolate calcium, 35 mg pyridoxal-5'-phosphate, and 2 mg methylcobalamin) were administered at a dosage of two tablets daily. Primary outcome indicators were the percent change in mean retinal sensitivity threshold measured by macular microperimetry and the percent change in mean central retinal thickness measured by spectral-domain optical coherence tomography.
resultsThree subjects were lost to follow-up. In the remaining seven subjects, two of 14 eyes had foveal edema that prevented microperimetry measurements due to poor fixation. The remaining 12 eyes showed a nonlinear improvement in mean threshold retinal sensitivity (P < 0.001). Overall change in mean central retinal thickness in 14 eyes was linear (R(2) = 0.625; P = 0.034), with a significant reduction between one and six months (P = 0.012).
conclusionIn this pilot study, the Metanx intervention appeared to have some beneficial effects with respect to reducing retinal edema and increasing light sensitivity in subjects with nonproliferative diabetic retinopathy.
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Registered trials
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