ArticleProceedings of the National Academy of Sciences of the United States of America2013
Poststimulus undershoots in cerebral blood flow and BOLD fMRI responses are modulated by poststimulus neuronal activity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 98 citations in OpenAlex.
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- Changes in high-frequency aperiodic 1/f slope and periodic activity reflect post-stimulus functional inhibition in the visual cortex.Imaging neuroscience (Cambridge, Mass.) · 2024Article
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- Separating vascular and neuronal effects of age on fMRI BOLD signals.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
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- Post-stimulus beta responses are modulated by task duration.NeuroImage · 2020Article
- Decoding Neural Responses to Motion-in-Depth Using EEG.Frontiers in neuroscience · 2020Article
- Late fMRI Response Components Are Altered in Autism Spectrum Disorder.Frontiers in human neuroscience · 2020Article
- Wearable neuroimaging: Combining and contrasting magnetoencephalography and electroencephalography.NeuroImage · 2019Article
- Gradient theories of brain activation: A novel application to studying the parental brain.Current behavioral neuroscience reports · 2019Article
- Disconnected and Hyperactive: A Replication of Sensorimotor Cortex Abnormalities in Patients With Schizophrenia During Proactive Response Inhibition.Schizophrenia bulletin · 2019Article
- Cerebral tissue pONeuroscience letters · 2019Article
- Exploring the relative efficacy of motion artefact correction techniques for EEG data acquired during simultaneous fMRI.Human brain mapping · 2019Article
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Authors and funding
5 authors at 2 institutions in 1 country.
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Abstract
fMRI is the foremost technique for noninvasive measurement of human brain function. However, its utility is limited by an incomplete understanding of the relationship between neuronal activity and the hemodynamic response. Though the primary peak of the hemodynamic response is modulated by neuronal activity, the origin of the typically negative poststimulus signal is poorly understood and its amplitude assumed to covary with the primary response. We use simultaneous recordings of EEG with blood oxygenation level-dependent (BOLD) and cerebral blood flow (CBF) fMRI during unilateral median nerve stimulation to show that the poststimulus fMRI signal is neuronally modulated. We observe high spatial agreement between concurrent BOLD and CBF responses to median nerve stimulation, with primary signal increases in contralateral sensorimotor cortex and primary signal decreases in ipsilateral sensorimotor cortex. During the poststimulus period, the amplitude and directionality (positive/negative) of the BOLD signal in both contralateral and ipsilateral sensorimotor cortex depends on the poststimulus synchrony of 8-13 Hz EEG neuronal activity, which is often considered to reflect cortical inhibition, along with concordant changes in CBF and metabolism. Therefore we present conclusive evidence that the fMRI time course represents a hemodynamic signature of at least two distinct temporal phases of neuronal activity, substantially improving understanding of the origin of the BOLD response and increasing the potential measurements of brain function provided by fMRI. We suggest that the poststimulus EEG and fMRI responses may be required for the resetting of the entire sensory network to enable a return to resting-state activity levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.