ArticleProceedings of the National Academy of Sciences of the United States of America2013
Sound response mediated by the TRP channels NOMPC, NANCHUNG, and INACTIVE in chordotonal organs of Drosophila larvae.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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72 citing papers in PubMed, 157 citations in OpenAlex.
- Cold sensing by a glutamate receptor drives avoidance behavior in Drosophila larvae.Current biology : CB · 2026Article
- Space-Dependent Oviposition Preference in Drosophila.Neuroscience bulletin · 2026Article
- TRP Channels from Sensory Coding to Physiology.Metabolites · 2025Review
- Genome-Wide Identification of the Transient Receptor Potential Channel Family in Nile Tilapia and Expression Analysis in Response to Cold Stress.Animals : an open access journal from MDPI · 2025Article
- Identification of candidate mechanosensory transduction channels in the aquatic insect Protohermes xanthodes (Megaloptera: Corydalidae) by transcriptome analysis.Journal of insect science (Online) · 2025Article
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- Statistical signature of subtle behavioral changes in large-scale assays.PLoS computational biology · 2025Article
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- Mechanically evoked spike responses of pentascolopidial chordotonal organs of Drosophila melanogaster larvae.The Journal of experimental biology · 2024Article
- IFT88 maintains sensory function by localising signalling proteins alongLife science alliance · 2024Article
- Dendrite intercalation between epidermal cells tunes nociceptor sensitivity to mechanical stimuli in Drosophila larvae.PLoS genetics · 2024Article
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- Cryo-EM structure of TMEM63C suggests it functions as a monomer.Nature communications · 2023Article
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- Dendrite intercalation between epidermal cells tunes nociceptor sensitivity to mechanical stimuli inbioRxiv : the preprint server for biology · 2023Article
- Wide-field fluorescence lifetime imaging of neuron spiking and subthreshold activity in vivo.Science (New York, N.Y.) · 2023Article
- The Voltage-Gated Sodium Channel ineNeuro · 2023Article
- Cross-modal modulation gates nociceptive inputs in Drosophila.Current biology : CB · 2023Article
- Article
12 more citing papers are in PubMed but not listed here.
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4 authors at 2 institutions in 1 country.
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Abstract
Mechanical stimuli, including tactile and sound signals, convey a variety of information important for animals to navigate the environment and avoid predators. Recent studies have revealed that Drosophila larvae can sense harsh or gentle touch with dendritic arborization (da) neurons in the body wall and can detect vibration with chordotonal organs (Cho). Whether they can also detect and respond to vibration or sound from their predators remains an open question. Here we report that larvae respond to sound of wasps and yellow jackets, as well as to pure tones of frequencies that are represented in such natural sounds, with startle and burrowing behaviors. The larval response to sound/vibration requires Cho neurons and, to a lesser extent, class IV da neurons. Our calcium imaging and electrophysiological experiments reveal that Cho neurons, but not class IV da neurons, are excited by natural sounds or pure tones, with tuning curves and intensity dependence appropriate for the behavioral responses. Furthermore, our study implicates the transient receptor potential (TRP) channels NOMPC, NANCHUNG, and INACTIVE, but not the dmPIEZO channel, in the mechanotransduction and/or signal amplification for the detection of sound by the larval Cho neurons. These findings indicate that larval Cho, like their counterparts in the adult fly, use some of the same mechanotransduction channels to detect sound waves and mediate the sensation akin to hearing in Drosophila larvae, allowing them to respond to the appearance of predators or other environmental cues at a distance with behaviors crucial for survival.
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