ArticleProceedings of the National Academy of Sciences of the United States of America2013
Lipid bilayer and cytoskeletal interactions in a red blood cell.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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68 citing papers in PubMed, 193 citations in OpenAlex.
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- A Computationally Efficient Viscoelastic Eukaryotic Cell Model.Annals of biomedical engineering · 2025Article
- In silico biophysics and rheology of blood and red blood cells in Gaucher Disease.PLoS computational biology · 2025Article
- Variability in the Deformability of Red Blood Cells: Application to Treating Premature Newborns with Blood Transfusion.International journal of molecular sciences · 2025Article
- Article
- Dynamic mechanisms for membrane skeleton transitions.Journal of cell science · 2025Article
- Stomatocyte-discocyte-echinocyte transformations of erythrocyte modulated by membrane-cytoskeleton mechanical properties.Biophysical journal · 2025Article
- In silico biophysics and rheology of blood and red blood cells in Gaucher Disease.bioRxiv : the preprint server for biology · 2024Article
- Mechanically induced topological transition of spectrin regulates its distribution in the mammalian cell cortex.Nature communications · 2024Article
- Two-component macrophage model for active phagocytosis with pseudopod formation.Biophysical journal · 2024Article
- Dynamic mechanisms for membrane skeleton transitions.bioRxiv : the preprint server for biology · 2024Article
- Signaling-biophysical modeling unravels mechanistic control of red blood cell phagocytosis by macrophages in sickle cell disease.PNAS nexus · 2024Article
- A computational model for the transit of a cancer cell through a constricted microchannel.Biomechanics and modeling in mechanobiology · 2023Article
- Effects of membrane viscoelasticity on the red blood cell dynamics in a microcapillary.Biophysical journal · 2023Article
- In silico modeling of patient-specific blood rheology in type 2 diabetes mellitus.Biophysical journal · 2023Article
- Lingering Dynamics of Type 2 Diabetes Mellitus Red Blood Cells in Retinal Arteriolar Bifurcations.Journal of functional biomaterials · 2022Article
- Optical-force-controlled red-blood-cell microlenses for subwavelength trapping and imaging.Biomedical optics express · 2022Article
- μMap-Red: Proximity Labeling by Red Light Photocatalysis.Journal of the American Chemical Society · 2022Article
8 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
We study the biomechanical interactions between the lipid bilayer and the cytoskeleton in a red blood cell (RBC) by developing a general framework for mesoscopic simulations. We treated the lipid bilayer and the cytoskeleton as two distinct components and developed a unique whole-cell model of the RBC, using dissipative particle dynamics (DPD). The model is validated by comparing the predicted results with measurements from four different and independent experiments. First, we simulated the micropipette aspiration and quantified the cytoskeletal deformation. Second, we studied the membrane fluctuations of healthy RBCs and RBCs parasitized to different intraerythrocytic stages by the malaria-inducing parasite Plasmodium falciparum. Third, we subjected the RBC to shear flow and investigated the dependence of its tank-treading frequency on shear rate. Finally, we simulated the bilayer-cytoskeletal detachment in channel flow to quantify the strength of such interactions when the corresponding bonds break. Taken together, these experiments and corresponding systematic DPD simulations probe the governing constitutive response of the cytoskeleton, elastic stiffness, viscous friction, and strength of bilayer-cytoskeletal interactions as well as membrane viscosities. Hence, the DPD simulations and comparisons with available independent experiments serve as validation of the unique two-component model and lead to useful insights into the biomechanical interactions between the lipid bilayer and the cytoskeleton of the RBC. Furthermore, they provide a basis for further studies to probe cell mechanistic processes in health and disease in a manner that guides the design and interpretation of experiments and to develop simulations of phenomena that cannot be studied systematically by experiments alone.
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