ArticleProceedings of the National Academy of Sciences of the United States of America2013
Phase-resetting mechanism of the circadian clock in Chlamydomonas reinhardtii.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- Too dim, too bright, and just right: Systems analysis of the Chlamydomonas diurnal program under limiting and excess light.The Plant cell · 2025Article
- Direct experimental observation of blue-light-induced conformational change and intermolecular interactions of cryptochrome.Communications biology · 2022Article
- Red Light Resets the Expression Pattern, Phase, and Period of the Circadian Clock in Plants: A Computational Approach.Biology · 2022Article
- A potential EARLY FLOWERING 3 homolog in Chlamydomonas is involved in the red/violet and blue light signaling pathways for the degradation of RHYTHM OF CHLOROPLAST 15.PLoS genetics · 2022Article
- Evolution of circadian clocks along the green lineage.Plant physiology · 2022Article
- The role of ROC75 as a daytime component of the circadian oscillator in Chlamydomonas reinhardtii.PLoS genetics · 2020Article
- Exposure to Artificial Light at Night and the Consequences for Flora, Fauna, and Ecosystems.Frontiers in neuroscience · 2020Review
- Nonlinear phase coupling functions: a numerical study.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2019Article
- Isolation of photoprotective signal transduction mutants by systematic bioluminescence screening in Chlamydomonas reinhardtii.Scientific reports · 2019Article
- Quantitative Phosphoproteomic and System-Level Analysis of TOR Inhibition Unravel Distinct Organellar Acclimation inFrontiers in plant science · 2018Article
- An Animal-Like Cryptochrome Controls thePlant physiology · 2017Article
- A Plant Cryptochrome Controls Key Features of thePlant physiology · 2017Article
- CSL encodes a leucine-rich-repeat protein implicated in red/violet light signaling to the circadian clock in Chlamydomonas.PLoS genetics · 2017Article
- Diversity of plant circadian clocks: Insights from studies of Chlamydomonas reinhardtii and Physcomitrella patens.Plant signaling & behavior · 2016Article
- Cyclin-Dependent Kinase Regulation of Diurnal Transcription in Chlamydomonas.The Plant cell · 2015Article
- Probing entrainment of Ostreococcus tauri circadian clock by green and blue light through a mathematical modeling approach.Frontiers in genetics · 2015Article
- High-throughput phenotyping of chlamydomonas swimming mutants based on nanoscale video analysis.Biophysical journal · 2014Article
- Chlamydomonas reinhardtii strain CC-124 is highly sensitive to blue light in addition to green and red light in resetting its circadian clock, with the blue-light photoreceptor plant cryptochrome likely acting as negative modulator.Plant physiology and biochemistry : PPB · 2014Article
- Using natural selection to explore the adaptive potential of Chlamydomonas reinhardtii.PloS one · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the circadian clock is a self-sustaining oscillator having a periodicity of nearly 1 d, its period length is not necessarily 24 h. Therefore, daily adjustment of the clock (i.e., resetting) is an essential mechanism for the circadian clock to adapt to daily environmental changes. One of the major cues for this resetting mechanism is light. In the unicellular green alga Chlamydomonas reinhardtii, the circadian clock is reset by blue/green and red light. However, the underlying molecular mechanisms remain largely unknown. In this study, using clock protein-luciferase fusion reporters, we found that the level of RHYTHM OF CHLOROPLAST 15 (ROC15), a clock component in C. reinhardtii, decreased rapidly after light exposure in a circadian-phase-independent manner. Blue, green, and red light were able to induce this process, with red light being the most effective among them. Expression analyses and inhibitor experiments suggested that this process was regulated mainly by a proteasome-dependent protein degradation pathway. In addition, we found that the other clock gene, ROC114, encoding an F-box protein, was involved in this process. Furthermore, we demonstrated that a roc15 mutant showed defects in the phase-resetting of the circadian clock by light. Taken together, these data strongly suggest that the light-induced degradation of ROC15 protein is one of the triggers for resetting the circadian clock in C. reinhardtii. Our data provide not only a basis for understanding the molecular mechanisms of light-induced phase-resetting in C. reinhardtii, but also insights into the phase-resetting mechanisms of circadian clocks in plants.
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