Evidence map›Paper›PMID 23898156›Full record

ArticleArchives of disease in childhood2013

Blinding in pharmacological trials: the devil is in the details.

Mandy Wan, Mine Orlu-Gul, Helene Legay, Catherine Tuleu

Abstract read
In one paragraph

Article in Archives of disease in childhood, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Manual Therapy Effect in Placebo-Controlled Trials: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Inhibition of the norepinephrine transporter to treat neurogenic orthostatic hypotension: is this the end of the story?Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021
    Article
  13. Article
  14. Blinding in Clinical Trials: Seeing the Big Picture.Medicina (Kaunas, Lithuania) · 2021
    Review
  15. Intense bitterness of molecules: Machine learning for expediting drug discovery.Computational and structural biotechnology journal · 2021
    Article
  16. Article
  17. Article
  18. Review
  19. A pre-trial evaluation of blinding for a Chinese herbal medicine trial.Contemporary clinical trials communications · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mandy WanNational Institute for Health Research-Medicines for Children Research Network-London & South East, Evelina London Children's Hospital, Guy's and St Thomas NHS Foundation Trust, King's Health Partners, London, UK. mandy.wan@gstt.nhs.uk
Mine Orlu-Gul
Helene Legay
Catherine Tuleu

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Double-Blind MethodSingle-Blind MethodBiasClinical Trials as TopicHumansPlacebosResearch DesignPlacebosEvidence Based MedicineGeneral Paediatrics

Identifiers

PMID23898156
PMCPMC3833301

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.