ArticleThe Journal of biological chemistry2013
Vitellogenin recognizes cell damage through membrane binding and shields living cells from reactive oxygen species.
Article in The Journal of biological chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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Who cites it
53 citing papers in PubMed, 131 citations in OpenAlex.
- Disruption of Antioxidant Defense Systems in Honey Bees and Wild Bees Under Environmental Xenobiotic Pressure.Antioxidants (Basel, Switzerland) · 2026Review
- Population Genetic Study ofEcology and evolution · 2026Article
- Article
- Susceptibility to the Neonicotinoid Pesticide Imidacloprid Is Linked to Life History Regulation in Honey Bees (Apis mellifera L.).Molecular ecology · 2026Article
- Innate defense mechanisms against Nosema ceranae in hygienic honey bee (Apis mellifera) colonies.PloS one · 2026Article
- Age, caste, and social context shape ovarian morphology and transcriptomic profiles in red harvester ants.npj aging · 2025Article
- Elevated virus infection of honey bee queens reduces methyl oleate production and destabilizes colony-level social structure.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Evidence for vitellogenin DNA-binding in honey bees.Protein science : a publication of the Protein Society · 2025Article
- Assessing structure-function impacts on Vitellogenin by leveraging allelic variant found in honey bee subspeciesiScience · 2025Article
- Cryo-EM structure of native honey bee vitellogenin.Nature communications · 2025Article
- Hypoxia extends lifespan but does not alter telomere length or oxidative stress in a solitary bee (Megachile rotundata).The Journal of experimental biology · 2025Article
- Review
- Roles of Vitellogenin and Its Receptor Genes in Female Reproduction of the Cigarette Beetle,Insects · 2025Article
- Vitellogenins Level as a Biomarker of the Honeybee Colony Strength in Urban and Rural Conditions.Insects · 2024Article
- Antioxidant Activity and Mechanism of Action of Amwaprin: A Protein in Honeybee (Antioxidants (Basel, Switzerland) · 2024Article
- Genome-Wide Identification of Vitellogenin Gene Family and Comparative Analysis of Their Involvement in Ovarian Maturation inInternational journal of molecular sciences · 2024Article
- Leafhopper salivary vitellogenin mediates virus transmission to plant phloem.Nature communications · 2024Article
- Unusual functions of insect vitellogenins: minireview.Physiological research · 2023Review
- Microsporidian Nosema bombycis hijacks host vitellogenin and restructures ovariole cells for transovarial transmission.PLoS pathogens · 2023Article
- Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
Large lipid transfer proteins are involved in lipid transportation and diverse other molecular processes. These serum proteins include vitellogenins, which are egg yolk precursors and pathogen pattern recognition receptors, and apolipoprotein B, which is an anti-inflammatory cholesterol carrier. In the honey bee, vitellogenin acts as an antioxidant, and elevated vitellogenin titer is linked to prolonged life span in this animal. Here, we show that vitellogenin has cell and membrane binding activity and that it binds preferentially to dead and damaged cells. Vitellogenin binds directly to phosphatidylcholine liposomes and with higher affinity to liposomes containing phosphatidylserine, a lipid of the inner leaflet of cell membranes that is exposed in damaged cells. Vitellogenin binding to live cells, furthermore, improves cell oxidative stress tolerance. This study can shed more light on why large lipid transfer proteins have a well conserved α-helical domain, because we locate the lipid bilayer-binding ability of vitellogenin largely to this region. We suggest that recognition of cell damage and oxidation shield properties are two mechanisms that allow vitellogenin to extend honey bee life span.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.