ReviewThe American journal of psychiatry2013
New ethical issues for genetic counseling in common mental disorders.
Review in The American journal of psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- The Efficacy of Genetic Counseling for Psychiatric Disorders: a Meta-Analysis.Journal of genetic counseling · 2017Pooled it
- Ethical and social issues in prediction of risk of severe mental illness: a scoping review and thematic analysis.BMC psychiatry · 2025Article
- Decoding the genetic landscape of autism: A comprehensive review.World journal of clinical pediatrics · 2024Article
- Ethics of early detection of disease risk factors: A scoping review.BMC medical ethics · 2024Article
- An ethical analysis of divergent clinical approaches to the application of genetic testing for autism and schizophrenia.Human genetics · 2022Article
- Psychiatric genetic counseling for patients with schizophrenia and their families.Frontiers in psychiatry · 2022Article
- Pharmacogenetics of Antipsychotic Treatment in Schizophrenia.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Copy Number Variants and Polygenic Risk Scores Predict Need of Care in Autism and/or ADHD Families.Journal of autism and developmental disorders · 2021Article
- Genetic and epigenetic analyses of panic disorder in the post-GWAS era.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- Evidence-Based Genetic Counseling for Psychiatric Disorders: A Road Map.Cold Spring Harbor perspectives in medicine · 2020Review
- European Psychiatric Association policy paper on ethical aspects in communication with patients and their families.European psychiatry : the journal of the Association of European Psychiatrists · 2020Article
- Psychiatric genomics researchers' perspectives on best practices for returning results to individual participants.Genetics in medicine : official journal of the American College of Medical Genetics · 2020Article
- Ethical Questions Linked to Rare Diseases and Orphan Drugs - A Systematic Review.Risk management and healthcare policy · 2020Article
- The transcription factor POU3F2 regulates a gene coexpression network in brain tissue from patients with psychiatric disorders.Science translational medicine · 2018Article
- What Should a Psychiatrist Know About Genetics? Review and Recommendations From the Residency Education Committee of the International Society of Psychiatric Genetics.The Journal of clinical psychiatry · 2018Review
- The role of genetics and genomics in clinical psychiatry.Dialogues in clinical neuroscience · 2018Review
- The challenges of the expanded availability of genomic information: an agenda-setting paper.Journal of community genetics · 2018Article
- Predictive Psychiatric Genetic Testing in Minors: An Exploration of the Non-Medical Benefits.Journal of bioethical inquiry · 2018Article
- Blue Genes? Understanding and Mitigating Negative Consequences of Personalized Information about Genetic Risk for Depression.Journal of genetic counseling · 2018Article
- Referrals to Mental Health Services: Exploring the Referral Process in Genetic Counseling.Journal of genetic counseling · 2018Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
objectiveRecent genetic findings of high-impact genetic variants in bipolar disorder, schizophrenia, and autism spectrum disorder (ASD) must lead to profound changes in genetic and family counseling. The authors present risk calculations, discuss the ethical implications of these findings, and outline the changes now required in the risk counseling process.
methodThe authors use data from recent mega-analyses and reviews of common and rare risk variants in bipolar disorder, schizophrenia, and ASD to calculate risks of illness based on genetic marker tests. They then consider new ethical issues in mental disorders presented by these risks, including within-family conflicts over genetic testing; effects of genetic discoveries on stigma, abortion, preimplantation procedures, and population screening for susceptibility; and genetic tests as a factor in marital choice.
resultsNew structural mutations (de novo copy number variants [CNVs], which are chromosomal microdeletions and micro-duplications) are present in 4%27% of patients with bipolar disorder, schizophrenia, or ASD and can occur almost anywhere in the genome. For a person with a de novo CNV, the absolute risk of bipolar disorder, schizophrenia, or ASD is 14%, much higher than the population risk. Rare CNVs have also been identified that are generally not new mutations but constitute very high-effect risk factors, ranging up to 82%.
conclusionsA substantial minority of patients with bipolar disorder, schizophrenia, and ASD have high-impact detectable genetic events. This greatly changes psychiatric genetic counseling for these patients and families. A psychotherapeutic approach may be needed as a routine part of risk counseling, particularly for resolution of ethical issues and for within-family stigma and conflicts over genetic test results.
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