ArticleScientific reports2013
Towards a better understanding of the novel avian-origin H7N9 influenza A virus in China.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 20 citations in OpenAlex.
- H7N9 influenza virus neutralizing antibodies that possess few somatic mutations.The Journal of clinical investigation · 2016Trial
- Phylogenetic Insights into H7Nx Influenza Viruses: Uncovering Reassortment Patterns and Geographic Variability.Viruses · 2024Article
- The host tropism of current zoonotic H7N9 viruses depends mainly on an acid-labile hemagglutinin with a single amino acid mutation in the stalk region.PLoS pathogens · 2024Article
- Preparation and application of chikungunya pseudovirus containing double reporter genes.Scientific reports · 2022Article
- Characterising routes of H5N1 and H7N9 spread in China using Bayesian phylogeographical analysis.Emerging microbes & infections · 2018Article
- Avian influenza.EFSA journal. European Food Safety Authority · 2017Article
- Epidemiological, clinical, and virologic features of two family clusters of avian influenza A (H7N9) virus infections in Southeast China.Scientific reports · 2017Article
- Characterizations of H4 avian influenza viruses isolated from ducks in live poultry markets and farm in Shanghai.Scientific reports · 2016Article
- Computational approach for predicting the conserved B-cell epitopes of hemagglutinin H7 subtype influenza virus.Experimental and therapeutic medicine · 2016Article
- Phylogenetic analysis and pathogenicity of H3 subtype avian influenza viruses isolated from live poultry markets in China.Scientific reports · 2016Article
- Inhibition of neuraminidase by Ganoderma triterpenoids and implications for neuraminidase inhibitor design.Scientific reports · 2015Article
- Seasonal Influenza Can Poise Hosts for CD4 T-Cell Immunity to H7N9 Avian Influenza.The Journal of infectious diseases · 2015Article
- Molecular docking of potential inhibitors for influenza H7N9.Computational and mathematical methods in medicine · 2015Article
- Multiple introductions of highly pathogenic avian influenza H5N1 viruses into Bangladesh.Emerging microbes & infections · 2014Article
- Predicting host tropism of influenza A virus proteins using random forest.BMC medical genomics · 2014Article
- Phylogenetic analysis of H7N9 avian influenza virus based on a novel mathematical descriptor.BioMed research international · 2014Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, a highly dangerous bird flu has infected over 130 patients in China, and the outbreak was attributed to a novel avian-origin H7N9 virus. Here, we performed a systematic analysis of the virus. We clarified the controversial viewpoint on neuraminidase (NA) origin and confirmed it was reassorted from Korean wild birds with higher confidence, whereas common ancestors of pathogenic H7N9 genes existed only one or two years ago. Further analysis of NA sequences suggested that most variations are not drug resistant and current drugs are still effective for the therapy. We also identified a potentially optimal 9-mer epitope, which can be helpful for vaccine development. The interaction of hemagglutinin (HA) and human receptor analog was confirmed by structural modeling, while NA might influence cellular processes through a PDZ-binding motif. A simplified virus infection model was proposed. Taken together, our studies provide a better understanding of the newly reassorted H7N9 viruses.
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