ArticleAnnals of biomedical engineering2013
Tubular heart valves from decellularized engineered tissue.
Article in Annals of biomedical engineering, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 58 citations in OpenAlex.
- Innovative Sutureless Fabrication Strategy for Tissue-Engineered Pediatric Heart Valves Using an Evolutive Support System.Annals of biomedical engineering · 2026Article
- Advancements and Challenges in Tissue-Engineered Heart Valves: Integrating Biomechanics, Biomaterials, and Biomimetic Design for Functional Maturity.Biomimetics (Basel, Switzerland) · 2026Review
- Pediatric pulmonary valve replacements: Clinical challenges and emerging technologies.Bioengineering & translational medicine · 2023Review
- Natural Polymers in Heart Valve Tissue Engineering: Strategies, Advances and Challenges.Biomedicines · 2022Review
- Elucidating the signal for contact guidance contained in aligned fibrils with a microstructural-mechanical model.Journal of the Royal Society, Interface · 2022Article
- The effect of decellularisation on the real time mechanical fatigue of porcine aortic heart valve roots.PloS one · 2022Article
- Cell contact guidance via sensing anisotropy of network mechanical resistance.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Trilayered tissue construct mimicking the orientations of three layers of a native heart valve leaflet.Cell and tissue research · 2020Article
- Article
- Trilayered tissue structure with leaflet-like orientations developed through in vivo tissue engineering.Biomedical materials (Bristol, England) · 2019Article
- Behavior of valvular interstitial cells on trilayered nanofibrous substrate mimicking morphologies of heart valve leaflet.Acta biomaterialia · 2019Article
- Tissue-Engineered Heart Valves: A Call for Mechanistic Studies.Tissue engineering. Part B, Reviews · 2018Article
- Translational Challenges in Cardiovascular Tissue Engineering.Journal of cardiovascular translational research · 2017Review
- Implantation of a Tissue-Engineered Tubular Heart Valve in Growing Lambs.Annals of biomedical engineering · 2017Article
- Animal Models for Heart Valve Research and Development.Drug discovery today. Disease models · 2017Article
- Cyclic Stretch and Perfusion Bioreactor for Conditioning Large Diameter Engineered Tissue Tubes.Annals of biomedical engineering · 2016Article
- Improved Geometry of Decellularized Tissue Engineered Heart Valves to Prevent Leaflet Retraction.Annals of biomedical engineering · 2016Article
- Effects of Intermittent and Incremental Cyclic Stretch on ERK Signaling and Collagen Production in Engineered Tissue.Cellular and molecular bioengineering · 2016Article
- Functional Heart Valve Scaffolds Obtained by Complete Decellularization of Porcine Aortic Roots in a Novel Differential Pressure Gradient Perfusion System.Tissue engineering. Part C, Methods · 2015Article
- 6-month aortic valve implantation of an off-the-shelf tissue-engineered valve in sheep.Biomaterials · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A novel tissue-engineered heart valve (TEHV) was fabricated from a decellularized tissue tube mounted on a frame with three struts, which upon back-pressure cause the tube to collapse into three coapting "leaflets." The tissue was completely biological, fabricated from ovine fibroblasts dispersed within a fibrin gel, compacted into a circumferentially aligned tube on a mandrel, and matured using a bioreactor system that applied cyclic distension. Following decellularization, the resulting tissue possessed tensile mechanical properties, mechanical anisotropy, and collagen content that were comparable to native pulmonary valve leaflets. When mounted on a custom frame and tested within a pulse duplicator system, the tubular TEHV displayed excellent function under both aortic and pulmonary conditions, with minimal regurgitant fractions and transvalvular pressure gradients at peak systole, as well as well as effective orifice areas exceeding those of current commercially available valve replacements. Short-term fatigue testing of one million cycles with pulmonary pressure gradients was conducted without significant change in mechanical properties and no observable macroscopic tissue deterioration. This study presents an attractive potential alternative to current tissue valve replacements due to its avoidance of chemical fixation and utilization of a tissue conducive to recellularization by host cell infiltration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.