ArticleEuropean journal of immunology2013
Noncoordinate expression of J-chain and Blimp-1 define nurse shark plasma cell populations during ontogeny.
Article in European journal of immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- BRWD1 directs B cell epigenetic states required for germinal center initiation, maintenance and function.Nature communications · 2026Article
- Extrafollicular and Other Non-Germinal Center B Cell Responses: An Evolutionary Perspective.Immunological reviews · 2025Review
- The Janus (dual) model of immunoglobulin isotype evolution: Conservation and plasticity are the defining paradigms.Immunological reviews · 2024Review
- The immunoglobulin J chain is an evolutionarily co-opted chemokine.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- 450 million years in the making: mapping the evolutionary foundations of germinal centers.Frontiers in immunology · 2023Review
- Identification of the Fc-alpha/mu receptor in Xenopus provides insight into the emergence of the poly-Ig receptor (pIgR) and mucosal Ig transport.European journal of immunology · 2021Article
- Analysis of shark NCR3 family genes reveals primordial features of vertebrate NKp30.Immunogenetics · 2021Article
- The immunoglobulins of cartilaginous fishes.Developmental and comparative immunology · 2021Review
- Bamboo Shark as a Small Animal Model for Single Domain Antibody Production.Frontiers in bioengineering and biotechnology · 2021Article
- Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses.Immunity · 2020Article
- Proof of long-term immunological memory in cartilaginous fishes.Developmental and comparative immunology · 2020Article
- A Synchronous IRF4-Dependent Gene Regulatory Network in B and Helper T Cells Orchestrating the Antibody Response.Trends in immunology · 2020Review
- B Cell Activation and Response Regulation During Viral Infections.Viral immunology · 2020Review
- A Hard(y) Look at B-1 Cell Development and Function.Journal of immunology (Baltimore, Md. : 1950) · 2017Review
- Blimp-1-dependent and -independent natural antibody production by B-1 and B-1-derived plasma cells.The Journal of experimental medicine · 2017Article
- Fish Immunoglobulins.Biology · 2016Review
- Emergence and Evolution of Secondary Lymphoid Organs.Annual review of cell and developmental biology · 2016Review
- Characteristics of natural antibody-secreting cells.Annals of the New York Academy of Sciences · 2015Review
- Natural and induced B-1 cell immunity to infections raises questions of nature versus nurture.Annals of the New York Academy of Sciences · 2015Article
- Structural and genetic diversity in antibody repertoires from diverse species.Current opinion in structural biology · 2015Review
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
B-lymphocyte-induced maturation protein 1 (Blimp-1) is the master regulator of plasma cell development, controlling genes such as those encoding J-chain and secretory Ig heavy chain. However, some mammalian plasma cells do not express J-chain, and mammalian B1 cells secrete "natural" IgM antibodies without upregulating Blimp-1. While these results have been controversial in mammalian systems, here we describe subsets of normally occurring Blimp-1(-) antibody-secreting cells in nurse sharks, found in lymphoid tissues at all ontogenic stages. Sharks naturally produce large amounts of both pentameric (classically "19S") and monomeric (classically "7S") IgM, the latter an indicator of adaptive immunity. Consistent with the mammalian paradigm, shark Blimp-1 is expressed in splenic 7S IgM-secreting cells, though rarely detected in the J-chain(+) cells producing 19S IgM. Although IgM transcript levels are lower in J-chain(+) cells, these cells nevertheless secrete 19S IgM in the absence of Blimp-1, as demonstrated by ELISPOT and metabolic labeling. Additionally, cells in the shark BM equivalent (epigonal) are Blimp-1(-). Our data suggest that, in sharks, 19S-secreting cells and other secreting memory B cells in the epigonal are maintained for long periods without Blimp-1, but like in mammals, Blimp-1 is required for terminating the B-cell program following an adaptive immune response in the spleen.
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