ArticleMolecules (Basel, Switzerland)2013
Antidiarrheal activity of 19-deoxyicetexone isolated from Salvia ballotiflora Benth in mice and rats.
Article in Molecules (Basel, Switzerland), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Diterpenes with Abietane and Clerodane Skeletons from the MexicanMolecules (Basel, Switzerland) · 2026Review
- Recent Developments with Icetexane Natural Products.Chemistry & biodiversity · 2022Review
- A Review on the Ethnopharmacology and Phytochemistry of the Neotropical Sages (Frontiers in pharmacology · 2022Review
- Evaluation of Antidiarrheal Activity of 80% Methanolic Extract of the Leaves ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- The Anti-diarrheal Activity of the Non-toxic Dihuang Powder in Mice.Frontiers in pharmacology · 2018Article
- Phytochemical and pharmacological evaluation of ethanolic extract of Lepisanthes rubiginosa L. leaves.BMC complementary and alternative medicine · 2017Article
- Structure, Absolute Configuration, and Antiproliferative Activity of Abietane and Icetexane Diterpenoids from Salvia ballotiflora.Molecules (Basel, Switzerland) · 2017Article
- Preparation ofEvidence-based complementary and alternative medicine : eCAM · 2017Article
- Antidiarrheal activity of crude methanolic root extract of Idigofera spicata Forssk.(Fabaceae).BMC complementary and alternative medicine · 2016Article
- Experimental assessment of antidiarrheal and antisecretory activity of 80% methanolic leaf extract of Zehneria scabra in mice.BMC complementary and alternative medicine · 2014Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The antidiarrheal properties of 19-deoxyicetexone, a diterpenoid isolated from Salvia ballotiflora were evaluated on castor oil-, arachidonic acid (AA)- and prostaglandin (PGE₂)-induced diarrhea in rodent models. The structure of 19-deoxyicetexone was determined by X-ray crystallography, mass spectrometry (EI-MS), as well as ultraviolet (UV-Vis), infrared (FT-IR) and nuclear magnetic resonance (NMR) spectroscopies. This compound significantly and dose-dependently reduced frequency of stooling in castor oil-induced diarrhea, and at dose of 25 mg/kg it also inhibited diarrhea induced with AA, while it had no effect on PGE₂-induced diarrhea. This compound at doses of 25 mg/kg also diminished castor oil-induced enteropooling and intestinal motility, and inhibited the contraction of the rats' ileum induced by carbachol chloride at a concentration of 100 µg/mL. 19-Deoxyicetexone did not present acute toxicity at doses of 625 mg/kg. Its antidiarrheal activity may be due to increased reabsorption of NaCl and water and inhibition of the release of prostaglandins, gastrointestinal motility and fluid accumulation in the intestinal tracts of rats. These findings suggest that 19-deoxyicetexone may be used in the treatment of diarrhea, although more studies must be carried out to confirm this.
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