Evidence map›Paper›PMID 23896613›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2014

APOE interacts with age to modify rate of decline in cognitive and brain changes in Alzheimer's disease.

Yu-Ling Chang, Christine Fennema-Notestine, Dominic Holland, Linda K McEvoy, Nikki H Stricker, David P Salmon, Anders M Dale, Mark W Bondi, Alzheimer's Disease Neuroimaging Initiative

Abstract read
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In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Beyond binary classification: Comparing three region-based multi-phase Aβ staging systems.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  4. Article
  5. Cognitive trajectories diverge by genetic risk in a preclinical longitudinal cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
    Article
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  19. Genetic studies of quantitative MCI and AD phenotypes in ADNI: Progress, opportunities, and plans.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2015
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yu-Ling ChangDepartment of Psychology, National Taiwan University, Taipei, Taiwan.
Christine Fennema-NotestineDepartment of Psychiatry, University of California at San Diego, San Diego, CA, USA; Department of Radiology, University of California at San Diego, San Diego, CA, USA.
Dominic HollandDepartment of Neurosciences, University of California at San Diego, San Diego, CA, USA.
Linda K McEvoyDepartment of Radiology, University of California at San Diego, San Diego, CA, USA.
Nikki H StrickerVeterans Affairs Boston Healthcare System, Boston, MA, USA; Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA.
David P SalmonDepartment of Neurosciences, University of California at San Diego, San Diego, CA, USA.
Anders M DaleDepartment of Radiology, University of California at San Diego, San Diego, CA, USA; Department of Neurosciences, University of California at San Diego, San Diego, CA, USA.
Mark W BondiVeterans Affairs San Diego Healthcare System, San Diego, CA, USA; Department of Psychiatry, University of California at San Diego, San Diego, CA, USA. Electronic address: mbondi@ucsd.edu.
Alzheimer's Disease Neuroimaging Initiative

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8M
VIRUS-INDUCED BRAIN PATHOLOGYP50AG005131 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BREWER, JAMES B · 1985 to 2018
$55.4M
UC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI DECARLI, CHARLES · 1991 to 2020
$28.3M
Cognitive Abilities of At-Risk Elderly for DementiaR01AG012674 · NIA · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI BONDI, MARK W · 2001 to 2012
$2.7M
Structural & Metabolic Neuroimaging Biomarkers in Early Alzheimer's DiseaseR01AG031224 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DALE, ANDERS M · 2008 to 2012
$1.9M
Neuroimaging and Risk Factor Correlates in Aging and MCIK24AG026431 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BONDI, MARK W · 2007 to 2016
$1.7M
Structure and Functional Imaging of Age-Related Changes in Working MemoryK01AG029218 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCEVOY, LINDA KATHLEEN · 2007 to 2011
$558k
"MR Morphometrics and Cognitive Decline Rate in Large-Scale Aging Studies"K01AG030514 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CARMICHAEL, OWEN T. · 2008 to 2012
$495k
NIA NIH HHS K01 AG029218NIA NIH HHS K01AG029218NIA NIH HHS K01 AG030514NIA NIH HHS K24 AG026431NIA NIH HHS P30 AG010129NIA NIH HHS P50 AG005131NIA NIH HHS R01 AG012674NIA NIH HHS R01 AG031224NIA NIH HHS R01 AG05131NIA NIH HHS U01 AG024904NIA NIH HHS U24 AG021886
6 · The paper itself

Abstract

objectiveTo determine (1) whether age-standardized cognitive declines and brain morphometric change differ between Young-Old patients with Alzheimer's disease (YOAD) and Very-Old patients with Alzheimer's disease (VOAD), and (2) whether the apolipoprotein E (APOE) genotype modifies these neuropsychological and morphometric changes.

methodsBaseline and 12-month follow-up neuropsychological and morphometric measures were examined for healthy control subjects and patients with AD. The two AD groups were divided further into subgroups on the basis of the presence of at least one APOE ε4 allele.

resultsThe YOAD group showed more severe deficits and steeper declines in cognition than the VOAD group. Moreover, the presence of an APOE ε4 allele had a more deleterious effect on the YOAD group than the VOAD group on cognition and brain structure both cross-sectionally and longitudinally.

conclusionsResults underscore the importance of integrating an individual's age and genetic susceptibility--and their interaction--when examining neuropsychological and neuroimaging changes in the early stages of Alzheimer's disease.

Indexed as

AgedAged, 80 and overAge FactorsAlzheimer DiseaseApolipoprotein E4BrainCross-Sectional StudiesFemaleFollow-Up StudiesGenetic Predisposition to DiseaseGenotypeHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle AgedApolipoprotein E4Alzheimer's diseaseAPOE genotypeCognitionLongitudinalMagnetic resonance imagingMorphometry

Identifiers

PMID23896613
PMCPMC3815680

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.