Evidence map›Paper›PMID 23896610›Full record

ArticleBioorganic & medicinal chemistry2013

Effect of ring-constrained phenylpropyloxyethylamines on sigma receptors.

Lidiya Stavitskaya, Michael J Seminerio, Jason R Healy, Bahar Noorbakhsh, Rae R Matsumoto, Andrew Coop

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lidiya StavitskayaDepartment of Pharmaceutical Sciences, University of Maryland, School of Pharmacy, 20 N. Pine Street, Baltimore, MD 21201, USA.
Michael J Seminerio
Jason R Healy
Bahar Noorbakhsh
Rae R Matsumoto
Andrew Coop
West Virginia University · USUniversity of Maryland, Baltimore · US

Funding

OPIOIDS WITH DELTA ANTAGONIST AND MU AGONIST ACTIVITYR01DA013583 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI COOP, ANDREW · 2001 to 2012
$2.5M
Synthesis &Evaluation of Cocaine AntagonistsR01DA013978 · NIDA · WEST VIRGINIA UNIVERSITY · PI MATSUMOTO, RAE R · 2001 to 2010
$1.9M
Reversing the toxic effects of drugs of abuseK02DA019634 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI COOP, ANDREW · 2005 to 2009
$528k
NIDA NIH HHS DA013978NIDA NIH HHS DA19634NIDA NIH HHS K02 DA019634NIDA NIH HHS R01 DA013583NIDA NIH HHS R01 DA013978
6 · The paper itself

Abstract

A series of ring-constrained phenylpropyloxyethylamines, partial opioid structure analogs and derivatives of a previously studied sigma (σ) receptor ligand, was synthesized and evaluated at σ and opioid receptors for receptor selectivity. The results of this study identified several compounds with nanomolar affinity at both σ receptor subtypes. Compounds 6 and 9 had the highest selectivity for both σ receptor subtypes, compared to μ opioid receptors. In addition, compounds 6 and 9 significantly reduced the convulsive effects of cocaine in mice, which would be consistent with antagonism of σ receptors.

Indexed as

AnimalsCocaineConvulsantsCyclohexanolsEthylaminesMicePhenethylaminesPropylaminesProtein BindingReceptors, sigmaSeizures2-(methyl(3-phenylpropyl)amino)cyclohexanol2-(methyl(phenethyl)amino)cyclohexanolCocaineConvulsantsCyclohexanolsEthylaminesPhenethylaminesPropylaminesReceptors, sigmaAntagonistsOpioidPhenylpropyloxyethylamineslSigma

Identifiers

PMID23896610
PMCPMC8463110
OpenAlexW2030283792

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.