ReviewAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2013
Population ancestry and genetic risk for diabetes and kidney, cardiovascular, and bone disease: modifiable environmental factors may produce the cures.
Review in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Trends in prevalence of comorbidities in heart failure clinical trials.European journal of heart failure · 2020Pooled it
- Global geographical variation in patient characteristics in percutaneous coronary intervention clinical trials: A systematic review and meta-analysis.American heart journal · 2018Pooled it
- Deceased donor multidrug resistance protein 1 and caveolin 1 gene variants may influence allograft survival in kidney transplantation.Kidney international · 2015Pooled it
- Genetic European Ancestry and Incident Diabetes in Black Individuals: Insights From the SPRINT Trial.Circulation. Genomic and precision medicine · 2022Trial
- Plasma apoM and S1P levels are inversely associated with mortality in African Americans with type 2 diabetes mellitus.Journal of lipid research · 2019Trial
- Association of Joint Genetic and Social Environmental Risks With Incident Myocardial Infarction: Results From the Health and Retirement Study.Journal of the American Heart Association · 2023Article
- Molecular Genetic Testing for Kidney Disorders During the COVID-19 Pandemic.Delaware journal of public health · 2021Article
- Article
- Preventing CKD in Low- and Middle-Income Countries: A Call for Urgent Action.Kidney international reports · 2020Review
- Human genetics and genomics research in Ecuador: historical survey, current state, and future directions.Human genomics · 2019Article
- Rationale and design of a placebo controlled randomized trial to assess short term, high-dose oral cholecalciferol on select laboratory and genomic responses in African Americans with hypovitaminosis D.Contemporary clinical trials · 2018Article
- Cerebral Structure and Cognitive Performance in African Americans and European Americans With Type 2 Diabetes.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Article
- Somatic T-cell Receptor Diversity in a Chronic Kidney Disease PatientPopulation Linked to Electronic Health Records.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2018Article
- FGF23 Concentration andDiabetes care · 2018Article
- Associations of Early Kidney Disease With Brain Magnetic Resonance Imaging and Cognitive Function in African Americans With Type 2 Diabetes Mellitus.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2017Article
- African Ancestry-Specific Alleles and Kidney Disease Risk in Hispanics/Latinos.Journal of the American Society of Nephrology : JASN · 2017Article
- Social Determinants of Racial Disparities in CKD.Journal of the American Society of Nephrology : JASN · 2016Review
- Mitochondrial and genomic ancestry are associated with etiology of heart failure in Brazilian patients.Journal of human hypertension · 2016Article
- Subclinical Atherosclerosis Is Inversely Associated With Gray Matter Volume in African Americans With Type 2 Diabetes.Diabetes care · 2015Article
- Apolipoprotein L1, income and early kidney damage.BMC nephrology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Variable rates of disease observed between members of different continental population groups may be mediated by inherited factors, environmental exposures, or their combination. This article provides evidence in support of differential allele frequency distributions that underlie the higher rates of nondiabetic kidney disease in the focal segmental glomerulosclerosis spectrum of disease and lower rates of coronary artery calcified atherosclerotic plaque and osteoporosis in populations of African ancestry. With recognition that these and other common complex diseases are affected by biological factors comes the realization that targeted manipulation of environmental exposures and pharmacologic treatments will have different effects based on genotype. The present era of precision medicine will couple one's genetic makeup with specific therapies to reduce rates of disease based on the presence of disease-specific alleles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.