Evidence map›Paper›PMID 23896059›Full record

ArticleLeukemia research2013

Gene expression profiling of murine T-cell lymphoblastic lymphoma identifies deregulation of S-phase initiating genes.

Magdalena Julia Dabrowska, Ditte Ejegod, Louise Berkhoudt Lassen, Hans Erik Johnsen, Matthias Wabl, Finn Skou Pedersen, Karen Dybkær

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Magdalena Julia DabrowskaDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark. magdalena_dabrowska@ymail.com
Ditte Ejegod
Louise Berkhoudt Lassen
Hans Erik Johnsen
Matthias Wabl
Finn Skou Pedersen
Karen Dybkær
Aarhus University · DKAalborg University Hospital · DKUniversity of California, San Francisco · US

Funding

GENE TARGETED MICE WITH A SIMPLIFIED IMMUNE SYSTEMR01AI041570 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WABL, MATTHIAS R · 1998 to 2014
$4.6M
NIAID NIH HHS R01 AI041570
6 · The paper itself

Abstract

In a search for genes and pathways implicated in T-cell lymphoblastic lymphoma (T-LBL) development, we used a murine lymphoma model, where mice of the NMRI-inbred strain were inoculated with murine leukemia virus mutants. The resulting tumors were analyzed by integration analysis and global gene expression profiling to determine the effect of the retroviral integrations on the nearby genes, and the deregulated pathways in the tumors. Gene expression profiling identified increased expression of genes involved in the minichromosome maintenance and origin of recognition pathway as well as downregulation in negative regulators of G1/S transition, indicating increased S-phase initiation in murine T-LBLs.

Indexed as

Gene Expression ProfilingGenes, cdcAnimalsCell Transformation, ViralCluster AnalysisGene Expression Regulation, NeoplasticLeukemia Virus, MurineMiceModels, BiologicalPrecursor Cell Lymphoblastic Leukemia-LymphomaS PhaseVirus IntegrationGene expression ProfilingInsertional mutagenesisMLVMouse modelSL3-3T-cell lymphoblastic lymphomaT-LBL

Identifiers

PMID23896059
PMCPMC4057920
OpenAlexW2003975374

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.