ArticleChemosphere2013
Inflammatory stress response in A549 cells as a result of exposure to coal: evidence for the role of pyrite in coal workers' pneumoconiosis pathogenesis.
Article in Chemosphere, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Potential Health Impacts, Treatments, and Countermeasures of Martian Dust on Future Human Space Exploration.GeoHealth · 2025Review
- Machine Learning Demonstrates Dominance of Physical Characteristics over Particle Composition in Coal Dust Toxicity.Environmental science & technology · 2024Article
- The impact of coal mine dust characteristics on pathways to respiratory harm: investigating the pneumoconiotic potency of coals.Environmental geochemistry and health · 2023Review
- Anomalous Enrichment of As and Hg in Underground Coal Dust: A Case from Xishan Coalfield, Shanxi Province, North China.ACS omega · 2023Article
- Article
- No association between pyrite content and lung cell responses to coal particles.Scientific reports · 2021Article
- Article
- Absence of Cytotoxicity towards Microglia of Iron Oxide (α-FeToxicology research · 2016Article
- A Scourge Returns: Black Lung in Appalachia.Environmental health perspectives · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
unlabelledOn the basis of a recent epidemiological study it is hypothesized that pyrite content in coal is an important factor in coal workers' pneumoconiosis (CWP) pathogenesis. While the role of pyrite in pathogenesis remains to be resolved, the ability of the mineral to generate reactive oxygen species (ROS) through various mechanisms is likely a contributing factor. The aim of this study was to elucidate the importance of the pyrite content of coal in generating an inflammatory stress response (ISR), which is defined as the upregulation of ROS normalized by cell viability. The ISR of A549 human lung epithelial cells in the presence of natural coal samples with variable pyrite contents was measured. Normalized to surface area, five particle loadings for each coal reference standard were analyzed systematically for a total of 24 h. The ISR generated by coals containing 0.00, 0.01, and 0.49 wt.% pyritic sulfur is comparable to,though less than, the ISR generated by inert glass beads (299% of the control). The coals containing 0.52 and 1.15 wt.% pyritic sulfur generated the greatest ISR (798% and 1426% of the control, respectively).
conclusionsWhile ISR does not increase proportionally to pyrite content in coal, the two coals with the highest pyritic sulfur and available iron contents generate the greatest ISR. Therefore, the present study indicates that coals with elevated pyrite contents are likely to induce a significant health burden by stimulating inflammation within the lungs, and may contribute to the development of CWP.
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