ArticleNeural development2013
Dicer is required for neural stem cell multipotency and lineage progression during cerebral cortex development.
Article in Neural development, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Uncoupling neocortical neuron fate and migration via a Let-7-RBX2 axis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Stage-specific expression patterns and co-targeting relationships among miRNAs in the developing mouse cerebral cortex.Communications biology · 2024Article
- Generation and transcriptomic characterization of MIR137 knockout miniature pig model for neurodevelopmental disorders.Cell & bioscience · 2024Article
- Transcription of microRNAs is regulated by developmental signaling pathways and transcription factors.Frontiers in cell and developmental biology · 2024Article
- MicroRNA Profiling of Self-Renewing Human Neural Stem Cells Reveals Novel Sets of Differentially Expressed microRNAs During Neural Differentiation In Vitro.Stem cell reviews and reports · 2023Article
- Review
- The microRNA-17 ~ 92 Family as a Key Regulator of Neurogenesis and Potential Regenerative Therapeutics of Neurological Disorders.Stem cell reviews and reports · 2022Review
- Evolving features of human cortical development and the emerging roles of non-coding RNAs in neural progenitor cell diversity and function.Cellular and molecular life sciences : CMLS · 2021Article
- MicroRNA Signatures of the Developing Primate Fovea.Frontiers in cell and developmental biology · 2021Article
- Length of the Neurogenic Period-A Key Determinant for the Generation of Upper-Layer Neurons During Neocortex Development and Evolution.Frontiers in cell and developmental biology · 2021Review
- MicroRNAs Instruct and Maintain Cell Type Diversity in the Nervous System.Frontiers in molecular neuroscience · 2021Review
- Adult Neural Stem Cell Regulation by Small Non-coding RNAs: Physiological Significance and Pathological Implications.Frontiers in cellular neuroscience · 2021Article
- Repression of Irs2 by let-7 miRNAs is essential for homeostasis of the telencephalic neuroepithelium.The EMBO journal · 2020Article
- Sliced Human Cortical Organoids for Modeling Distinct Cortical Layer Formation.Cell stem cell · 2020Article
- Sugarcane (Frontiers in cell and developmental biology · 2020Article
- Let-7 regulates cell cycle dynamics in the developing cerebral cortex and retina.Scientific reports · 2019Article
- A comprehensive review of the genetic and biological evidence supports a role for MicroRNA-137 in the etiology of schizophrenia.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2018Review
- Review
- Growth of malignant extracranial tumors alters microRNAome in the prefrontal cortex of TumorGraft mice.Oncotarget · 2017Article
- Decoding the ubiquitous role of microRNAs in neurogenesis.Molecular neurobiology · 2017Review
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5 authors.
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Abstract
backgroundDuring cerebral cortex development, multipotent neural progenitor cells generate a variety of neuronal subtypes in a fixed temporal order. How a single neural progenitor cell generates the diversity of cortical projection neurons in a temporal sequence is not well understood. Based on their function in developmental timing in other systems, Dicer and microRNAs are potential candidate regulators of cellular pathways that control lineage progression in neural systems.
resultsCortex-specific deletion of Dicer results in a marked reduction in the cellular complexity of the cortex, due to a pronounced narrowing in the range of neuronal types generated by Dicer-null cortical stem and progenitor cells. Instead of generating different classes of lamina-specific neurons in order over the 6-day period of neurogenesis, Dicer null cortical stem and progenitor cells continually produce one class of deep layer projection neuron. However, gliogenesis in the Dicer-null cerebral cortex was not delayed, despite the loss of multipotency and the failure of neuronal lineage progression.
conclusionsWe conclude that Dicer is required for regulating cortical stem cell multipotency with respect to neuronal diversity, without affecting the larger scale switch from neurogenesis to gliogenesis. The differences in phenotypes reported from different timings of Dicer deletion indicate that the molecular pathways regulating developmental transitions are notably dosage sensitive.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.