ArticleInhalation toxicology2013
Effects of copy center particles on the lungs: a toxicological characterization using a Balb/c mouse model.
Article in Inhalation toxicology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Incineration-Generated Polyethylene Micro-Nanoplastics Increase Triglyceride Lipolysis and Absorption in anEnvironmental science & technology · 2022Article
- Printer center nanoparticles alter the DNA repair capacity of human bronchial airway epithelial cells.NanoImpact · 2022Article
- Potential hazardous effects of printing room PM2.5 exposure include promotion of lung inflammation and subsequent injury.Molecular medicine reports · 2020Article
- Pilot deep RNA sequencing of worker blood samples from Singapore printing industry for occupational risk assessment.NanoImpact · 2020Article
- Inflammation Increases Susceptibility of Human Small Airway Epithelial Cells to Pneumonic Nanotoxicity.Small (Weinheim an der Bergstrasse, Germany) · 2020Article
- Inhalation of printer-emitted particles impairs cardiac conduction, hemodynamics, and autonomic regulation and induces arrhythmia and electrical remodeling in rats.Particle and fibre toxicology · 2020Article
- Inducible nitric oxide synthase inhibitor, 1400W, mitigates DFP-induced long-term neurotoxicity in the rat model.Neurobiology of disease · 2020Article
- Long-term observation of pulmonary toxicity of toner with external additives following a single intratracheal instillation in rats.Journal of occupational health · 2020Article
- Integrated Transcriptomics, Metabolomics, and Lipidomics Profiling in Rat Lung, Blood, and Serum for Assessment of Laser Printer-Emitted Nanoparticle Inhalation Exposure-Induced Disease Risks.International journal of molecular sciences · 2019Article
- The influence of PMExperimental and therapeutic medicine · 2019Article
- Assessment of environmental and ergonomic hazard associated to printing and photocopying: a review.Environmental geochemistry and health · 2019Review
- Inhaled nanomaterials and the respiratory microbiome: clinical, immunological and toxicological perspectives.Particle and fibre toxicology · 2018Review
- Oxidative stress and cell cycle arrest induced by short-term exposure to dustfall PMEnvironmental science and pollution research international · 2018Article
- Interface effect of natural precipitated dust on the normal flora of Escherichia coli and Staphylococcus epidermidis.Environmental science and pollution research international · 2018Article
- Nanoparticle exposures from nano-enabled toner-based printing equipment and human health: state of science and future research needs.Critical reviews in toxicology · 2017Review
- Preparation, characterization, and in vitro dosimetry of dispersed, engineered nanomaterials.Nature protocols · 2017Article
- Predicting Concentrations of Ultrafine Particles and Volatile Organic Compounds Resulting from Desktop 3D Printer Operation and the Impact of Potential Control Strategies.Journal of industrial ecology · 2017Article
- Toxicological Implications of Released Particulate Matter during Thermal Decomposition of Nano-Enabled Thermoplastics.NanoImpact · 2017Article
- Development and characterization of electronic-cigarette exposure generation system (Ecig-EGS) for the physico-chemical and toxicological assessment of electronic cigarette emissions.Inhalation toxicology · 2016Article
- A cohort study of the acute and chronic respiratory effects of toner exposure among handlers: a longitudinal analyses from 2004 to 2013.Industrial health · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
contextPrinters and photocopiers release respirable particles into the air. Engineered nanomaterials (ENMs) have been recently incorporated into toner formulations but their potential toxicological effects have not been well studied.
objectiveTo evaluate the biological responses to copier-emitted particles in the lungs using a mouse model.
methodsParticulate matter (PM) from a university copy center was sampled and fractionated into three distinct sizes, two of which (PM0.1 and PM0.1-2.5) were evaluated in this study. The particles were extracted and dispersed in deionized water and RPMI/10% FBS. Hydrodynamic diameter and zeta potential were evaluated by dynamic light scattering. The toxicological potential of these particles was studied using 8-week-old male Balb/c mice. Mice were intratracheally instilled with 0.2, 0.6, 2.0 mg/kg bw of either the PM0.1 and PM0.1-2.5 size fractions. Fe2O3 and welding fumes were used as comparative materials, while RPMI/10% FBS was used as the vehicle control. Bronchoalveolar lavage (BAL) was performed 24 hours post-instillation. The BAL fluid was analyzed for total and differential cell counts, and biochemical markers of injury and inflammation.
resultsParticle size- and dose-dependent pulmonary effects were found. Specifically, mice instilled with PM0.1 (2.0 mg/kg bw) had significant increases in neutrophil number, lactate dehydrogenase and albumin compared to vehicle control. Likewise, pro-inflammatory cytokines were elevated in mice exposed to PM0.1 (2.0 mg/kg bw) compared to other groups.
conclusionOur results indicate that exposure to copier-emitted nanoparticles may induce lung injury and inflammation. Further exposure assessment and toxicological investigations are necessary to address this emerging environmental health pollutant.
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