ArticleAlcoholism, clinical and experimental research2013
Effects of caffeine on alcohol consumption and nicotine self-administration in rats.
Article in Alcoholism, clinical and experimental research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Receptor and metabolic insights on the ability of caffeine to prevent alcohol-induced stimulation of mesolimbic dopamine transmission.Translational psychiatry · 2024Article
- Receptor and metabolic insights on the ability of caffeine to prevent alcohol-induced stimulation of mesolimbic dopamine transmission.Research square · 2024Article
- Adolescent intermittent ethanol exposure enhances adult stress effects in male rats.Pharmacology, biochemistry, and behavior · 2023Article
- Neurochemical and Behavioral Consequences of Ethanol and/or Caffeine Exposure: Effects in Zebrafish and Rodents.Current neuropharmacology · 2022Review
- Effect of caffeine on alcohol drinking in mice.Alcohol (Fayetteville, N.Y.) · 2021Article
- Caffeine modulates pharmacokinetic and pharmacodynamic profiles of pioglitazone in diabetic rats: Impact on therapeutics.Saudi medical journal · 2021Article
- Chronic voluntary caffeine intake in male Wistar rats reveals individual differences in addiction-like behavior.Pharmacology, biochemistry, and behavior · 2020Article
- Rewarding and aversive doses of caffeine alter activity but not conditioned place preference induced by ethanol in DBA/2J mice.Pharmacology, biochemistry, and behavior · 2019Article
- Mutually augmenting interactions of dextromethorphan and sazetidine-A for reducing nicotine self-administration in rats.Pharmacology, biochemistry, and behavior · 2018Article
- Differential efficacies of the nicotinic α4β2 desensitizing agents in reducing nicotine self-administration in female rats.Psychopharmacology · 2017Article
- Smoking and caffeine consumption: a genetic analysis of their association.Addiction biology · 2017Article
- Effects of caffeine on alcohol reinforcement: beverage choice, self-administration, and subjective ratings.Psychopharmacology · 2017Article
- Interactions between nicotine and drugs of abuse: a review of preclinical findings.The American journal of drug and alcohol abuse · 2017Review
- Nicotinic acetylcholine receptor availability in cigarette smokers: effect of heavy caffeine or marijuana use.Psychopharmacology · 2016Article
- Desire to Drink Alcohol is Enhanced with High Caffeine Energy Drink Mixers.Alcoholism, clinical and experimental research · 2016Article
- Concomitant Caffeine Increases Binge Consumption of Ethanol in Adolescent and Adult Mice, But Produces Additive Motor Stimulation Only in Adolescent Animals.Alcoholism, clinical and experimental research · 2016Article
- Associations between smoking and caffeine consumption in two European cohorts.Addiction (Abingdon, England) · 2016Observational
- Who uses alcohol mixed with energy drinks? Characteristics of college student users.Journal of American college health : J of ACH · 2016Article
- Sensitization and Tolerance Following Repeated Exposure to Caffeine and Alcohol in Mice.Alcoholism, clinical and experimental research · 2015Article
- Can energy drinks increase the desire for more alcohol?Advances in nutrition (Bethesda, Md.) · 2015Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundCaffeine, alcohol, and nicotine are 3 of the most widespread self-administered psychoactive substances, which are known to be extensively co-administered. However, little is known about the degree to which they may mutually potentiate each other's consumption.
methodsIn the current set of studies, we examined in rats the effect of caffeine administration on alcohol drinking and intravenous (i.v.) self-administration of nicotine. In male alcohol-preferring (P) rats, caffeine (5, 10, and 20 mg/kg) or the saline vehicle was administered acutely either by subcutaneous (S.C.) injection or orally (PO) by gavage. In a chronic study, the effect of PO caffeine (5 and 20 mg/kg) on alcohol intake over a 10-day period was tested. In another experiment, the effect of acute PO administration of caffeine (20 mg/kg) or saline on saccharin intake (0.2% solution) was determined in P rats. Effects of 20 mg/kg caffeine on motor activity were also determined in P rats. Finally, the effects of acute PO caffeine administration on nicotine self-administration in Sprague-Dawley rats were also determined.
resultsBoth routes of administration of caffeine, S.C. and PO, caused a significant dose-related decrease in alcohol intake and preference during free access to alcohol and after 4-day deprivation of alcohol. However, the low dose of 5 mg/kg caffeine increased alcohol intake. Acute PO caffeine also reduced saccharin intake. Acute systemic administration of 20 mg/kg caffeine did not exert a significant effect on motor activity. In Sprague-Dawley rats trained to self-administer i.v. nicotine, acute PO administration of caffeine significantly increased self-administration of nicotine in a dose-related manner.
conclusionsThese results suggest that adenosine receptor systems may play a role in both alcohol and nicotine intake and deserve further study regarding these addictions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.