Trial reportNeurogastroenterology and motility2013
Gastric electrical stimulation with Enterra therapy improves symptoms of idiopathic gastroparesis.
Trial report in Neurogastroenterology and motility, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05039424 (A Randomized, Sham-controlled Trial), which is not on this map. Cited by 54 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized, Sham-controlled Trial: Endoscopic Myotomy of the Pylorus To Improve Emptying and Symptoms (EMPTIES)
Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 110 citations in OpenAlex.
- Gastroenterological Society of Australia Position Statement on the Assessment and Management of Idiopathic Gastroparesis.Journal of gastroenterology and hepatology · 2026Guideline
- Combined Gastric Electrical Stimulation and Pyloroplasty in Gastroparesis: A Randomized Clinical Trial.JAMA network open · 2025Trial
- Aprepitant Has Mixed Effects on Nausea and Reduces Other Symptoms in Patients With Gastroparesis and Related Disorders.Gastroenterology · 2018Trial
- Methods and Techniques for Closed-Loop Gastrointestinal Pacing.Neurogastroenterology and motility · 2026Article
- Severe Diabetic Gastroparesis and Complex Discharge Planning: Home IV Cyclizine As the Only Solution.Cureus · 2026Article
- Insights Into Functional Dyspepsia and Gastroparesis - Western Versus Asian Perspectives.Journal of neurogastroenterology and motility · 2025Review
- Gastroparesis, a diabetic complication causing further, even serious, complications: How to prevent its worsening?World journal of gastroenterology · 2025Article
- Gastric electrical stimulation versus standard medical therapies for long-term symptom control and improved quality of life in drug-refractory gastroparesis patients.Annals of medicine and surgery (2012) · 2025Review
- Outcome of gastric electrical stimulator with and without pyloromyotomy for refractory gastroparesis.Surgical endoscopy · 2024Article
- Outcome of gastric electrical stimulator with and without pyloromyotomy for refractory gastroparesis.Surgical endoscopy · 2024Article
- Diabetic gastroparesis: clinical features, diagnosis and management.Irish journal of medical science · 2023Review
- Electroceuticals for Neurogastroenterology and Motility Disorders.Current gastroenterology reports · 2023Review
- Reconsideration of the Gastroparetic Syndrome.Current gastroenterology reports · 2023Review
- Gastroparesis: Myths, Misconceptions, and Management.Clinical and experimental gastroenterology · 2023Review
- Gastric electric stimulator versus gastrectomy for the treatment of medically refractory gastroparesis.Surgical endoscopy · 2022Article
- Clinical application and research progress of extracellular slow wave recording in the gastrointestinal tract.World journal of gastrointestinal surgery · 2022Review
- POEM, GPOEM, and ZPOEM.Digestive diseases and sciences · 2022Review
- Gastric Electrical Stimulation: Role and Clinical Impact on Chronic Nausea and Vomiting.Frontiers in neuroscience · 2022Review
- Review
- A Systematic Review of the Therapeutic Role of Gastric Pacemakers in Adults With Gastroparesis.Cureus · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGastric electrical stimulation (GES) is a therapeutic option for intractable symptoms of gastroparesis (GP). Idiopathic GP (ID-GP) represents a subset of GP.
aimsA prospective, multicenter, double-blinded, randomized, crossover study to evaluate the safety and efficacy of Enterra GES in the treatment of chronic vomiting in ID-GP.
methodsThirty-two ID-GP subjects (mean age 39; 81% F, mean 7.7 years of GP) were implanted with GES. The stimulator was turned ON for 1½ months followed by double-blind randomization to consecutive 3-month crossover periods with the device either ON or OFF. ON stimulation was followed in unblinded fashion for another 4.5 months. Twenty-five subjects completed the crossover phase and 21 finished 1 year of follow-up. KEY
resultsDuring the unblinded ON period, there was a reduction in weekly vomiting frequency (WVF) from baseline (61.2%, P < 0.001). There was a non-significant reduction in WVF between ON vs OFF periods (the primary outcome) with median reduction of 17% (P > 0.10). Seventy-five percent of patients preferred the ON vs OFF period (P = 0.021). At 1 year, WVF remained decreased (median reduction = 87%, P < 0.001), accompanied by improvements in GP symptoms, gastric emptying and days of hospitalization (P < 0.05). CONCLUSIONS & INFERENCES: (i) In this prospective study of Enterra GES for ID-GP, there was a reduction in vomiting during the initial ON period; (ii) The double-blind 3-month periods showed a non-significant reduction in vomiting in the ON vs OFF period, the primary outcome variable; (iii) At 12 months with ON stimulation, there was a sustained decrease in vomiting and days of hospitalizations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.