ArticleBMC medical genetics2013
Associations between serotonin transporter gene polymorphisms and heat pain perception in adults with chronic pain.
Article in BMC medical genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 26 citations in OpenAlex.
- Unintended Prolonged Opioid Use: Protocol for a Case-Controlled Trial.JMIR research protocols · 2025Article
- Serotonin Transporter (5-Hydroxytryptamine Transporter, SERT, SLC6A4) and Sodium-dependent Reuptake Inhibitors as Modulators of Pain Behaviors and Analgesic Responses.The journal of pain · 2024Review
- Pharmacogenomics of Pain Management: The Impact of Specific Biological Polymorphisms on Drugs and Metabolism.Current oncology reports · 2020Review
- Identification of a de novo FOXP1 mutation and incidental discovery of inherited genetic variants contributing to a case of autism spectrum disorder and epilepsy.Molecular genetics & genomic medicine · 2019Article
- Update on the pharmacogenomics of pain management.Pharmacogenomics and personalized medicine · 2019Review
- A machine-learned analysis of human gene polymorphisms modulating persisting pain points to major roles of neuroimmune processes.European journal of pain (London, England) · 2018Article
- Fatal intoxication with antidepressants: a case with many culprits.Forensic science, medicine, and pathology · 2018Article
- Augmenting the antinociceptive effects of nicotinic acetylcholine receptor activity through lynx1 modulation.PloS one · 2018Article
- The triallelic serotonin transporter gene polymorphism is associated with depressive symptoms in adults with chronic pain.Journal of pain research · 2017Article
- Analgesic Effects of Danggui-Shaoyao-San on Various "Phenotypes" of Nociception and Inflammation in a Formalin Pain Model.Molecular neurobiology · 2016Article
- Pain, Genes, and Function in the Post-Hip Fracture Period.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2016Article
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- Is the experience of thermal pain genetics dependent?BioMed research international · 2015Review
- No association of polymorphisms in the serotonin transporter gene with thermal pain sensation in healthy individuals.Molecular pain · 2014Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe triallelic serotonin transporter gene linked polymorphic region (5-HTTLPR) has been associated with alterations in thermal pain perception. The primary aim of this study was to investigate the associations between heat pain (HP) perception and the triallelic 5-HTTLPR in a large cohort of adults with chronic pain.
methodsThe cohort included 277 adults with chronic pain who met inclusion criteria, and were consecutively admitted to an outpatient pain rehabilitation program from March 2009 through March 2010. Individuals were genotyped for the triallelic 5-HTTLPR (including rs25531) and categorized as high, intermediate, or low expressors of the serotonin transporter. Standardized measures of HP perception were obtained using a validated quantitative sensory test method of levels.
resultsThe distribution of the high, intermediate, and low expressing genotypes was 61 (22%), 149 (54%) and 67 (24%), respectively. The Hardy-Weinberg P-value was 0.204 which indicated no departure from equilibrium. A significant effect of genotype was observed for values of HP threshold (P = 0.029). Individual group comparisons showed that values of HP threshold were significantly greater in the intermediate compared to the high expressing group (P = 0.009) but not the low expressing group (P > 0.1). In a multiple variable linear regression model, the intermediate group (P = 0.034) and male sex (P = 0.021) were associated with significantly greater values of HP 0.5, but no significant genotype-by-sex interaction effect was observed.
conclusionsIn this study that involved adults with chronic pain, the intermediate triallelic 5-HTTLPR expressing group, but not the low expressing group, was associated with greater HP thresholds compared to the high expressing group.
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