Evidence map›Paper›PMID 23894696›Full record

ArticleBiomaterials science2013

Hydrogels Formed by Oxo-ester Mediated Native Chemical Ligation.

Iossif Strehin, Dmitri Gourevitch, Yong Zhang, Ellen Heber-Katz, Phillip B Messersmith

Abstract read
In one paragraph

Article in Biomaterials science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Thiol-Mediated Chemoselective Strategies forGels (Basel, Switzerland) · 2018
    Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Drug-induced regeneration in adult mice.Science translational medicine · 2015
    Article
  13. Chemical reactions directed Peptide self-assembly.International journal of molecular sciences · 2015
    Review
  14. Modular and orthogonal synthesis of hybrid polymers and networks.Chemical communications (Cambridge, England) · 2015
    Review
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Iossif StrehinNorthwestern University, Evanston, IL 60208, Biomedical Engineering Department, Materials Science and Engineering Department, Chemical and Biological Engineering Department, Chemistry of Life Processes Institute, Institute for Bionanotechnology in Medicine, Robert H. Lurie Comprehensive Cancer Center.
Dmitri Gourevitch
Yong Zhang
Ellen Heber-Katz
Phillip B Messersmith

Funding

Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Luis J Montaner · 1985 to 2026
$75.9M
Regenerative wound healing via inflammation-modulating biomaterialsR01DE021104 · NIDCR · WISTAR INSTITUTE · PI Georgios Hajishengallis, Ellen s. Heber-Katz · 2011 to 2026
$8.5M
Does Inflammation Enhance Rengeneration?R01DE021215 · NIDCR · WISTAR INSTITUTE · PI HEBER-KATZ, ELLEN S., MESSERSMITH, PHILLIP B · 2010 to 2013
$1.3M
NCI NIH HHS P30 CA010815NIDCR NIH HHS R01 DE021104NIDCR NIH HHS R01 DE021215
6 · The paper itself

Abstract

Oxo-ester mediated native chemical ligation (OMNCL) is a variation of the more general native chemical ligation (NCL) reaction that is widely employed for chemoselective ligation of peptide fragments. While OMNCL has been used for a variety of peptide ligations and for biomolecular modification of surfaces, it is typically practiced under harsh conditions that are unsuitable for use in a biological context. In this report we describe the use of OMNCL for polymer hydrogel formation, in-vitro cell encapsulation, and in-vivo implantation. Multivalent polymer precursors containing

Identifiers

PMID23894696
PMCPMC3719992

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.