ArticlePloS one2013
Soybean meal induces intestinal inflammation in zebrafish larvae.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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Who cites it
72 citing papers in PubMed, 222 citations in OpenAlex.
- Nutritional programming through early exposure to soybean meal: Effects on growth performance, intestinal health, metabolism, and microbiota of juvenile largemouth bass (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Short-term caloric restriction partially reprograms immune and microbial networks during acute DSS-induced colitis.Genes & nutrition · 2026Article
- Dietary responses of taste receptor genes to plant-based diets in farmed fish: A literature review.Open veterinary journal · 2026Review
- INHAND: Non-proliferative and proliferative lesions of fish - Chapter 3. Fish digestive system.Journal of toxicologic pathology · 2026Article
- Article
- Effects of Replacing Fishmeal with Soybean Meal on Intestinal Histology, Antioxidation, Endoplasmic Reticulum Stress, Inflammation, Tight Junction, and Microbiota in Olive Flounder (Animals : an open access journal from MDPI · 2025Article
- Parental social environment has transgenerational effects on zebrafish (Danio rerio) growth.Scientific reports · 2025Article
- Reducing dextran sodium sulfate interference with gene expression quantification in a mouse model of colitis.Journal of animal science · 2025Article
- Effects of Cholesterol Supplementation in High Soybean Meal Diet on Growth, Lipid Metabolism, and Intestinal Health of Juvenile Rice Field EelAquaculture nutrition · 2025Article
- Comprehensive Assessment of Rapeseed Meal as a Fish Meal Substitute in Hybrid Sturgeon (Aquaculture nutrition · 2025Article
- Identification of Single-Nucleotide Polymorphisms in Differentially Expressed Genes Favoring Soybean Meal Tolerance in Higher-Growth Zebrafish (Danio rerio).Marine biotechnology (New York, N.Y.) · 2024Article
- Isolation of Intestinal Macrophage Subpopulations for High-Quality Total RNA Purification in Zebrafish.Methods and protocols · 2024Article
- Growth, Survival, and Intestinal Health Alterations in Mediterranean Yellowtail (Current issues in molecular biology · 2024Article
- Article
- Chronic social isolation affects feeding behavior of juvenile zebrafish (Danio rerio).PloS one · 2024Article
- Edible Insects: A New Sustainable Nutritional Resource Worth Promoting.Foods (Basel, Switzerland) · 2023Review
- Enhancement of Soybean Meal Alters Gut Microbiome and Influences Behavior of Farmed Atlantic Salmon (Animals : an open access journal from MDPI · 2023Article
- The Role of Algae Extract (Veterinary sciences · 2023Article
- Ability ofInternational journal of molecular sciences · 2023Article
- Evaluation of Yeast Hydrolysate in a Low-Fishmeal Diet for Whiteleg Shrimp (Animals : an open access journal from MDPI · 2023Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The necessary replacement of fish meal with other protein source in diets of commercially important fish has prompted the study of the effect of the inclusion of different vegetable proteins sources on growth performance and on the gastro-intestinal tract. Currently, soybean meal is the primary protein source as a fish meal replacement because of its low price and high availability. Likewise, it is been documented that the ingestion of soybean meal by several fish species, such as salmonids and carp, triggers a type of intestinal inflammation called enteritis. In this paper, we analyzed the effects of the ingestion of soybean meal and two of its components, soy protein and soy saponin, on zebrafish to establish the basis for using zebrafish larvae as a model for fish nutrition. We took advantage of the existence of different transgenic lines, which allowed us to perform in vivo analysis. Our results indicated that larvae that were feed with soybean meal developed a clear intestinal inflammation as early as two day after beginning the diet. Moreover, we determined that is not the soy protein present in the diet but the soy saponin that is primarily responsible for triggering the immune response. These findings support the use of zebrafish screening assays to identify novel ingredients that would to improved current fish diets or would formulate new ones.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.