ArticlePloS one2013
Medical risk factors associated with cholangiocarcinoma in Taiwan: a population-based case-control study.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 7 of them syntheses that pooled it.
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Who cites it
46 citing papers in PubMed, 7 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Association between gallstones and the risk of biliary tract cancer: a systematic review and meta-analysis.Epidemiology and health · 2021Pooled it
- Association between nonalcoholic fatty liver disease and extrahepatic cancers: a systematic review and meta-analysis.Lipids in health and disease · 2020Pooled it
- Viral hepatitis B and C infections increase the risks of intrahepatic and extrahepatic cholangiocarcinoma: Evidence from a systematic review and meta-analysis.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2020Pooled it
- Non-alcoholic fatty liver disease as a risk factor for cholangiocarcinoma: a systematic review and meta-analysis.BMC gastroenterology · 2017Pooled it
- HBV Infection Status and the Risk of Cholangiocarcinoma in Asia: A Meta-Analysis.BioMed research international · 2016Pooled it
- Cholelithiasis and the risk of intrahepatic cholangiocarcinoma: a meta-analysis of observational studies.BMC cancer · 2015Pooled it
- Risk of primary liver cancer associated with gallstones and cholecystectomy: a meta-analysis.PloS one · 2014Pooled it
- Jaundice marks immunoglobulin G4-related cholangitis in type 1 autoimmune pancreatitis patients.Therapeutic advances in gastroenterology · 2026Article
- Burden and trajectories of biliary tract malignancies in Taiwan from 1998 to 2022.International journal of clinical oncology · 2025Article
- Cholecystitis and cholangiocarcinoma: a two-sample Mendelian randomization study.BMC gastroenterology · 2025Article
- Choledocholithiasis as a risk factor for cholangiocarcinoma: a nationwide retrospective cohort study.BMC gastroenterology · 2025Article
- Review
- Exploring the association between acute pancreatitis and biliary tract cancer: A large-scale population-based matched cohort study.United European gastroenterology journal · 2024Article
- Removal of intrahepatic bile duct stone could reduce the risk of cholangiocarcinoma: A single-center retrospective study in South Korea.World journal of clinical cases · 2024Article
- Review
- The link betweenAnnals of hepato-biliary-pancreatic surgery · 2023Review
- Viral hepatitis increases the risk of cholangiocarcinoma: a systematic review and meta-analysis.Translational cancer research · 2023Article
- Helicobacter Species and Hepato-Biliary Tract Malignancies: A Systematic Review and Meta-Analysis.Cancers · 2023Review
- Comparison of Risk Factors for Cholangiocarcinoma and Hepatocellular Carcinoma: A Prospective Cohort Study in Korean Adults.Cancers · 2022Article
- Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCholangiocarcinoma, including intra- and extrahepatic cholangiocarcinoma, is a rare but highly lethal cancer. Despite effort in finding the risk factors of cholangiocarcinoma, the causes of most cholangiocarcinoma remain unknown. This study utilized a population-based case-control design using data from the National Health Insurance Research Database (NHIRD) of Taiwan to assess the medical conditions associated with cholangiocarcinoma.
methods5,157 incident cases of cholangiocarcinoma diagnosed during 2004 to 2008 and 20,628 controls matched to the cases on sex, age, and time of diagnosis (reference date for the controls) were identified from the NHIRD. Medical risk factors were ascertained from the NHIRD for each individual. Conditional logistic regression was performed to evaluate the association between cholangiocarcinoma and each medical risk factor.
resultsThe results showed that factors associated with an increased risk of cholangiocarcinoma included cholangitis, cholelithiasis, cholecystitis, cirrhosis of liver, alcoholic liver disease, chronic non-alcoholic liver disease, hepatitis B, hepatitis C, diabetes, chronic pancreatitis, inflammatory bowel disease, and peptic ulcer. In addition, sex and age differences were observed.
conclusionsThis study confirms the association between cholangiocarcinoma and several less established risk factors, including diabetes, inflammatory bowel disease, hepatitis B, hepatitis C, and peptic ulcer (proxy for the presence of Helicobacter Pylori). Future studies should focus on finding additional environmental and genetic causes of cholangiocarcinoma.
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