ArticlePloS one2013
Global transcriptional responses of the toxic cyanobacterium, Microcystis aeruginosa, to nitrogen stress, phosphorus stress, and growth on organic matter.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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60 citing papers in PubMed, 172 citations in OpenAlex.
- Nutrient disturbance in a shallow aquaculture pond impacts Microcystis gene expression but does not impact bacterial community function during bloom conditions.Journal of phycology · 2026Article
- Secondary metabolism ofApplied and environmental microbiology · 2026Review
- Diverse Cyanopeptides follow distinct temporal succession patterns in freshwater harmful algal blooms.The ISME journal · 2026Article
- Dealing with phosphorus deficiency: contrasting strategies in marine phytoplankton and bacteria.ISME communications · 2026Article
- Elucidation of Mechanisms by Which Microplastics (PET) Facilitates the Rapid Growth of Benthic Cyanobacteria and Toxin Production in Aquatic Ecosystems.Metabolites · 2025Review
- Spatio-temporal dynamics of bacterial community composition in a Western European watershed, the Meuse River watershed.FEMS microbiology ecology · 2025Article
- Metatranscriptomics reveals gene expression dynamics during an anatoxin-a producing Dolichospermum bloom in a western coastal lake.Chemosphere · 2025Article
- Strain-specific strategies underlie convergent phosphate solubilization inISME communications · 2025Article
- Transcriptome Analysis of the Harmful DinoflagellateMicroorganisms · 2024Article
- Underway measurement of cyanobacterial microcystins using a surface plasmon resonance sensor on an autonomous underwater vehicle.Limnology and oceanography, methods · 2024Article
- Molecular mechanism of a coastal cyanobacteriumMarine life science & technology · 2024Article
- Sewage-and fertilizer-derived nutrients alter the intensity, diversity, and toxicity of harmful cyanobacterial blooms in eutrophic lakes.Frontiers in microbiology · 2024Article
- Microcystin congeners in Lake Erie follow the seasonal pattern of nitrogen availability.Harmful algae · 2023Article
- Cyanotoxins, biosynthetic gene clusters, and factors modulating cyanotoxin biosynthesis.World journal of microbiology & biotechnology · 2023Review
- Expression ofApplied and environmental microbiology · 2023Article
- Nitrogen forms and concentration influence the impact of titanium dioxide nanoparticles on the biomass and antioxidant enzyme activities of Microcystis aeruginosa.Archives of microbiology · 2023Article
- Transcriptomics Insights into Phosphorus Stress Response ofInternational journal of molecular sciences · 2023Article
- Schindler's legacy: from eutrophic lakes to the phosphorus utilization strategies of cyanobacteria.FEMS microbiology reviews · 2022Review
- Cyanotoxin-encoding genes as powerful predictors of cyanotoxin production during harmful cyanobacterial blooms in an inland freshwater lake: Evaluating a novel early-warning system.The Science of the total environment · 2022Article
- Nitrogen and phosphorus significantly alter growth, nitrogen fixation, anatoxin-a content, and the transcriptome of the bloom-forming cyanobacterium,Frontiers in microbiology · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whole transcriptome shotgun sequencing (RNA-seq) was used to assess the transcriptomic response of the toxic cyanobacterium Microcystis aeruginosa during growth with low levels of dissolved inorganic nitrogen (low N), low levels of dissolved inorganic phosphorus (low P), and in the presence of high levels of high molecular weight dissolved organic matter (HMWDOM). Under low N, one third of the genome was differentially expressed, with significant increases in transcripts observed among genes within the nir operon, urea transport genes (urtBCDE), and amino acid transporters while significant decreases in transcripts were observed in genes related to photosynthesis. There was also a significant decrease in the transcription of the microcystin synthetase gene set under low N and a significant decrease in microcystin content per Microcystis cell demonstrating that N supply influences cellular toxicity. Under low P, 27% of the genome was differentially expressed. The Pho regulon was induced leading to large increases in transcript levels of the alkaline phosphatase phoX, the Pst transport system (pstABC), and the sphX gene, and transcripts of multiple sulfate transporter were also significantly more abundant. While the transcriptional response to growth on HMWDOM was smaller (5-22% of genes differentially expressed), transcripts of multiple genes specifically associated with the transport and degradation of organic compounds were significantly more abundant within HMWDOM treatments and thus may be recruited by Microcystis to utilize these substrates. Collectively, these findings provide a comprehensive understanding of the nutritional physiology of this toxic, bloom-forming cyanobacterium and the role of N in controlling microcystin synthesis.
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