ArticlePloS one2013
Low-intensity pulsed ultrasound accelerates tooth movement via activation of the BMP-2 signaling pathway.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 4 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Efficacy of low-intensity pulsed ultrasound in orthodontic tooth movement and pain perception in human studies: a systematic review and meta-analysis.BMC oral health · 2026Pooled it
- Efficacy of low-intensity pulsed ultrasound in orthodontic tooth movement and orthodontically induced root resorption in animal and human studies: a systematic review and meta-analysis.Clinical oral investigations · 2024Pooled it
- Attenuation of orthodontically induced inflammatory root resorption by using low-intensity pulsed ultrasound as a therapeutic modality- a systematic review.BMC oral health · 2024Pooled it
- Minimally Invasive Techniques to Accelerate the Orthodontic Tooth Movement: A Systematic Review of Animal Studies.BioMed research international · 2015Pooled it
- Effect of low-intensity pulsed ultrasound on the duration of mandibular anterior crowding correction and pain perception in adults undergoing orthodontic treatment: a single-blinded randomized control trial.Dental press journal of orthodontics · 2025Trial
- Low-intensity pulsed ultrasound stimulation facilitates osteogenic differentiation of human periodontal ligament cells.PloS one · 2014Trial
- Article
- The Impact of Therapeutic Ultrasound on Bone Radio Density Following Orthodontic Treatment with Clear Aligners: A Preliminary StudyCurrent medical imaging · 2025Article
- The effects of fulvic acids and low-level laser therapy on orthodontic retention in rats.BMC oral health · 2024Article
- Applications of nanotechnology in orthodontics: a comprehensive review of tooth movement, antibacterial properties, friction reduction, and corrosion resistance.Biomedical engineering online · 2024Review
- Effect of autophagy on aging-related changes in orthodontic tooth movement in rats.BMC oral health · 2024Article
- Impact of concentrated growth factor (CGF) injection on acceleration of orthodontic tooth movement in rabbits.BMC oral health · 2024Article
- Influence of Ultrasound Stimulation on the Viability, Proliferation and Protein Expression of Osteoblasts and Periodontal Ligament Fibroblasts.Biomedicines · 2024Article
- Low-intensity pulsed ultrasound promotes the osteogenesis of mechanical force-treated periodontal ligament cells via Piezo1.Frontiers in bioengineering and biotechnology · 2024Article
- Effect of light-emitting photobiomodulation therapy on the rate of orthodontic tooth movement : A randomized controlled clinical trial.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2023Article
- The effect of low-frequency high-intensity ultrasound combined with aspirin on tooth movement in rats.BMC oral health · 2023Article
- Low-intensity pulsed ultrasound regulates osteoblast-osteoclast crosstalk via EphrinB2/EphB4 signaling for orthodontic alveolar bone remodeling.Frontiers in bioengineering and biotechnology · 2023Article
- Impact of low intensity pulsed ultrasound on volumetric root resorption of maxillary incisors in patients treated with clear aligner therapy: A retrospective study.Dental press journal of orthodontics · 2023Article
- Effectiveness of Combination of Chitosan Gel and Hydroxyapatite from Crabs Shells (International journal of biomaterials · 2022Article
- Low-Intensity Pulsed Ultrasound Promotes Osteogenic Potential of iPSC-Derived MSCs but Fails to Simplify the iPSC-EB-MSC Differentiation Process.Frontiers in bioengineering and biotechnology · 2022Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study was designed to determine the underlying mechanism of low-intensity pulsed ultrasound (LIPUS) induced alveolar bone remodeling and the role of BMP-2 expression in a rat orthodontic tooth movement model. Orthodontic appliances were placed between the homonymy upper first molars and the upper central incisors in rats under general anesthesia, followed by daily 20-min LIPUS or sham LIPUS treatment beginning at day 0. Tooth movement distances and molecular changes were evaluated at each observation point. In vitro and in vivo studies were conducted to detect HGF (Hepatocyte growth factor)/Runx2/BMP-2 signaling pathways and receptor activator of NFκB ligand (RANKL) expression by quantitative real time PCR (qRT-PCR), Western blot and immunohistochemistry. At day 3, LIPUS had no effect on the rat orthodontic tooth movement distance and BMP-2-induced alveolar bone remodeling. However, beginning at day 5 and for the following time points, LIPUS significantly increased orthodontic tooth movement distance and BMP-2 signaling pathway and RANKL expression compared with the control group. The qRT-PCR and Western blot data in vitro and in vivo to study BMP-2 expression were consistent with the immunohistochemistry observations. The present study demonstrates that LIPUS promotes alveolar bone remodeling by stimulating the HGF/Runx2/BMP-2 signaling pathway and RANKL expression in a rat orthodontic tooth movement model, and LIPUS increased BMP-2 expression via Runx2 regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.