ArticlePloS one2013
Glucose metabolism during resting state reveals abnormal brain networks organization in the Alzheimer's disease and mild cognitive impairment.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 2 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- Brain network disintegration as a final common pathway for delirium: a systematic review and qualitative meta-analysis.NeuroImage. Clinical · 2019Pooled it
- Resting-state abnormalities in amnestic mild cognitive impairment: a meta-analysis.Translational psychiatry · 2016Pooled it
- Metabolism-weighted brain connectome reveals synaptic integration and vulnerability to neurodegeneration.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Amyloid-β acute exposition affects the CA1 hippocampal network activity and its topological organization, evaluated with multielectrode arrays.Frontiers in dementia · 2026Article
- Disrupted Energetic and Entropic Landscape in Individuals With Mild Cognitive Impairment: Insights From Network Control Theory.Human brain mapping · 2025Article
- Amino Acid Compound 2 (AAC2) Treatment Counteracts Insulin-Induced Synaptic Gene Expression and Seizure-Related Mortality in a Mouse Model of Alzheimer's Disease.International journal of molecular sciences · 2024Article
- Connectivity based on glucose dynamics reveals exaggerated sensorimotor network coupling on subject-level in Parkinson's disease.European journal of nuclear medicine and molecular imaging · 2024Article
- The brain network hub degeneration in Alzheimer's disease.Biophysics reports · 2024Article
- Depletion and activation of microglia impact metabolic connectivity of the mouse brain.Journal of neuroinflammation · 2023Article
- Multimodality imaging of neurodegenerative disorders with a focus on multiparametric magnetic resonance and molecular imaging.Insights into imaging · 2023Review
- Resting-state electroencephalographic characteristics related to mild cognitive impairments.Frontiers in psychiatry · 2023Article
- Introducing a gatekeeping system for amyloid status assessment in mild cognitive impairment.European journal of nuclear medicine and molecular imaging · 2022Article
- Dysfunctional Glucose Metabolism in Alzheimer's Disease Onset and Potential Pharmacological Interventions.International journal of molecular sciences · 2022Review
- Contrasting Sodium and Potassium Perturbations in the Hippocampus Indicate Potential NaFrontiers in aging neuroscience · 2022Article
- BMNet: A New Region-Based Metric Learning Method for Early Alzheimer's Disease Identification With FDG-PET Images.Frontiers in neuroscience · 2022Article
- Pan-cerebral sodium elevations in vascular dementia: Evidence for disturbed brain-sodium homeostasis.Frontiers in aging neuroscience · 2022Article
- Individual cerebrocerebellar functional network analysis decoding symptomatologic dynamics of postoperative cerebellar mutism syndrome.Cerebral cortex communications · 2022Article
- Phenotypes and subphenotypes of delirium: a review of current categorisations and suggestions for progression.Critical care (London, England) · 2021Review
- Article
- Brain Molecular Connectivity in Neurodegenerative Conditions.Brain sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
This paper aims to study the abnormal patterns of brain glucose metabolism co-variations in Alzheimer disease (AD) and Mild Cognitive Impairment (MCI) patients compared to Normal healthy controls (NC) using the Alzheimer Disease Neuroimaging Initiative (ADNI) database. The local cerebral metabolic rate for glucose (CMRgl) in a set of 90 structures belonging to the AAL atlas was obtained from Fluro-Deoxyglucose Positron Emission Tomography data in resting state. It is assumed that brain regions whose CMRgl values are significantly correlated are functionally associated; therefore, when metabolism is altered in a single region, the alteration will affect the metabolism of other brain areas with which it interrelates. The glucose metabolism network (represented by the matrix of the CMRgl co-variations among all pairs of structures) was studied using the graph theory framework. The highest concurrent fluctuations in CMRgl were basically identified between homologous cortical regions in all groups. Significant differences in CMRgl co-variations in AD and MCI groups as compared to NC were found. The AD and MCI patients showed aberrant patterns in comparison to NC subjects, as detected by global and local network properties (global and local efficiency, clustering index, and others). MCI network's attributes showed an intermediate position between NC and AD, corroborating it as a transitional stage from normal aging to Alzheimer disease. Our study is an attempt at exploring the complex association between glucose metabolism, CMRgl covariations and the attributes of the brain network organization in AD and MCI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.