ArticlePloS one2013
Effects of late administration of pentoxifylline and tocotrienols in an image-guided rat model of localized heart irradiation.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- A pooled analysis of nine studies in one institution to assess effects of whole heart irradiation in rat models.International journal of radiation biology · 2024Article
- Pathomechanisms and therapeutic opportunities in radiation-induced heart disease: from bench to bedside.Clinical research in cardiology : official journal of the German Cardiac Society · 2021Review
- Longitudinal MRI study after carbon ion and photon irradiation: shorter latency time for myelopathy is not associated with differential morphological changes.Radiation oncology (London, England) · 2021Article
- Ramipril reduces incidence and prolongates latency time of radiation-induced rat myelopathy after photon and carbon ion irradiation.Journal of radiation research · 2020Article
- Radiation-induced myocardial fibrosis: Mechanisms underlying its pathogenesis and therapeutic strategies.Journal of cellular and molecular medicine · 2020Review
- Differences in Expression of Mitochondrial Complexes Due to Genetic Variants May Alter Sensitivity to Radiation-Induced Cardiac Dysfunction.Frontiers in cardiovascular medicine · 2020Article
- Radiotherapy-induced heart disease: a review of the literature.Precision clinical medicine · 2019Review
- New therapeutic insights into radiation-induced myocardial fibrosis.Therapeutic advances in chronic disease · 2019Review
- A Small Peptide Ac-SDKP Inhibits Radiation-Induced Cardiomyopathy.Circulation. Heart failure · 2018Article
- Antioxidant Tocols as Radiation Countermeasures (Challenges to be Addressed to Use Tocols as Radiation Countermeasures in Humans).Antioxidants (Basel, Switzerland) · 2018Review
- Advanced Small Animal Conformal Radiation Therapy Device.Technology in cancer research & treatment · 2017Article
- Pentoxifylline Attenuates Cardiac Remodeling Induced by Tobacco Smoke Exposure.Arquivos brasileiros de cardiologia · 2016Article
- Effects of local irradiation combined with sunitinib on early remodeling, mitochondria, and oxidative stress in the rat heart.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2016Article
- A tocotrienol-enriched formulation protects against radiation-induced changes in cardiac mitochondria without modifying late cardiac function or structure.Radiation research · 2015Article
- Combined mitigation of the gastrointestinal and hematopoietic acute radiation syndromes by an LPA2 receptor-specific nonlipid agonist.Chemistry & biology · 2015Article
- Vitamin E Analogs as Radiation Response Modifiers.Evidence-based complementary and alternative medicine : eCAM · 2015Review
- RhNRG-1β Protects the Myocardium against Irradiation-Induced Damage via the ErbB2-ERK-SIRT1 Signaling Pathway.PloS one · 2015Article
- Radiation-induced heart disease: an under-recognized entity?Current treatment options in cardiovascular medicine · 2014Article
- Effects of ionizing radiation on the heart.Mutation research. Reviews in mutation researchReview
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Radiation-induced heart disease (RIHD) is a long-term side effect of radiotherapy of intrathoracic, chest wall and breast tumors when radiation fields encompass all or part of the heart. Previous studies have shown that pentoxifylline (PTX) in combination with α-tocopherol reduced manifestations of RIHD in rat models of local heart irradiation. The relative contribution of PTX and α-tocopherol to these beneficial effects are not known. This study examined the effects of PTX alone or in combination with tocotrienols, forms of vitamin E with potential potent radiation mitigation properties. Rats received localized X-irradiation of the heart with an image-guided irradiation technique. At 3 months after irradiation rats received oral treatment with vehicle, PTX, or PTX in combination with a tocotrienol-enriched formulation. At 6 months after irradiation, PTX-treated rats showed arrhythmia in 5 out of 14 animals. PTX alone or in combination with tocotrienols did not alter cardiac radiation fibrosis, left ventricular protein expression of the endothelial markers von Willebrand factor and neuregulin-1, or phosphorylation of the signal mediators Akt, Erk1/2, or PKCα. On the other hand, tocotrienols reduced cardiac numbers of mast cells and macrophages, but enhanced the expression of tissue factor. While this new rat model of localized heart irradiation does not support the use of PTX alone, the effects of tocotrienols on chronic manifestations of RIHD deserve further investigation.
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