SynthesisPloS one2013
Respiratory infections in adults with atopic disease and IgE antibodies to common aeroallergens.
Synthesis in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Efficacy and safety of OM-85 in paediatric recurrent respiratory tract infections which could have a possible protective effect on COVID-19 pandemic: A meta-analysis.International journal of clinical practice · 2021Pooled it
- Infection risk in atopic dermatitis patients treated with biologics and JAK inhibitors: BioDay results.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025Article
- Parental Attitudes and Practices regarding Atopic Dermatitis: A Cross-Sectional Study among a Thai Population.Children (Basel, Switzerland) · 2024Article
- Bacterial lysate add-on therapy in adult and childhood asthma: a systematic review and meta-analysis.Journal of thoracic disease · 2023Article
- Asthma and Respiratory Infections From Birth to Young Adulthood.American journal of epidemiology · 2023Article
- Exacerbation of atopic dermatitis skin lesions in SARS-CoV-2 disease.Postepy dermatologii i alergologii · 2022Article
- Pollen Exposure and Cardiopulmonary Health Impacts in Adelaide, South Australia.International journal of environmental research and public health · 2022Article
- The Role of Allergen-Specific Immunotherapy in ENT Diseases: A Systematic Review.Journal of personalized medicine · 2022Review
- Acute Rhinosinusitis in Children with Inhalant Allergies.Children (Basel, Switzerland) · 2022Article
- Household mold exposure in association with childhood asthma and allergic rhinitis in a northwestern city and a southern city of China.Journal of thoracic disease · 2022Article
- A Real-World Effectiveness of Subcutaneous Immunotherapy on the Cost of Medication, Allergic Rhinitis, and Asthma Exacerbations, as well as Upper Respiratory Tract Infection in Subjects with Allergic Rhinitis with or without Asthma: A Retrospective Pilot Study.Medicina (Kaunas, Lithuania) · 2021Article
- Factors associated with IgG levels in adults with IgG subclass deficiency.BMC immunology · 2021Article
- Risk factors for recurrent respiratory tract infection in preschool-aged children.Pediatric research · 2021Article
- Immune Response to SARS-CoV-2 in an Asymptomatic Pediatric Allergic Cohort.Antibodies (Basel, Switzerland) · 2021Article
- Effect of congenital heart disease on the recurrence of cough variant asthma in children.BMC cardiovascular disorders · 2021Article
- International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis.International forum of allergy & rhinology · 2018Article
- Role of offending out-door aero-allergen and CD14 C(-159)T polymorphism in development and severity of asthma in a Kolkata patient population.African health sciences · 2017Article
- IgE sensitization to inhalant allergens and the risk of airway infection and disease: A population-based study.PloS one · 2017Article
- Impaired virus replication and decreased innate immune responses to viral infections in nasal epithelial cells from patients with allergic rhinitis.Clinical and experimental immunology · 2017Article
- Respiratory Diseases in University Students Associated with Exposure to Residential Dampness or Mold.International journal of environmental research and public health · 2016Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAtopic diseases, including allergic rhinitis, allergic dermatitis and asthma, are common diseases with a prevalence of 30-40% worldwide and are thus of great global public health importance. Allergic inflammation may influence the immunity against infections, so atopic individuals could be susceptible to respiratory infections. No previous population-based study has addressed the relation between atopy and respiratory infections in adulthood. We assessed the relation between atopic disease, specific IgE antibodies and the occurrence of upper and lower respiratory infections in the past 12 months among working-aged adults. METHODS AND
findingsA population-based cross-sectional study of 1008 atopic and non-atopic adults 21-63 years old was conducted. Information on atopic diseases, allergy tests and respiratory infections was collected by a questionnaire. Specific IgE antibodies to common aeroallergens were measured in serum. Adults with atopic disease had a significantly increased risk of lower respiratory tract infections (LRTI; including acute bronchitis and pneumonia) with an adjusted risk ratio (RR) 2.24 (95% confidence interval [CI] 1.43, 3.52) and upper respiratory tract infections (URTI; including common cold, sinusitis, tonsillitis, and otitis media) with an adjusted RR 1.55 (1.14, 2.10). The risk of LRTIs increased with increasing level of specific IgE (linear trend P = 0.059).
conclusionsThis study provides new evidence that working-aged adults with atopic disease experience significantly more LRTIs and URTIs than non-atopics. The occurrence of respiratory infections increased with increasing levels of specific IgE antibodies to common aeroallergens, showing a dose-response pattern with LRTIs. From the clinical point of view it is important to recognize that those with atopies are a risk group for respiratory infections, including more severe LRTIs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.