ArticlePloS one2013
Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed.
- Genomic insights into efflux-mediated biofilm persistence and multidrug resistance in Achromobacter xylosoxidans from cystic fibrosis.Archives of microbiology · 2026Article
- Genomic and transcriptomic insights intoMicrobiology (Reading, England) · 2026Article
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- From an emerging pathogen to therapeutic challenges: advances inFrontiers in microbiology · 2026Review
- Whole-genome sequences ofMicrobiology resource announcements · 2025Article
- Novel Insight into Dugong Mortality: First Report of SystemicAnimals : an open access journal from MDPI · 2025Article
- Achromobacter xylosoxidans modulates Pseudomonas aeruginosa virulence through a complex multi-target competition.Scientific reports · 2025Article
- Early bacterial communities in the lower airways and intestines of caesarean section neonates with respiratory disease.Frontiers in cellular and infection microbiology · 2025Article
- The twin-arginine translocation system is vital for cell adhesion and uptake of iron in the cystic fibrosis pathogenVirulence · 2024Article
- Pathogenesis ofInfection and immunity · 2023Article
- Shotgun Metagenomics Reveals Impacts of Copper and Water Heater Anodes on Pathogens and Microbiomes in Hot Water Plumbing Systems.Environmental science & technology · 2023Article
- CompoundingViruses · 2023Article
- Identification of Virulence Factors Involved in a Murine Model of Severe Achromobacter xylosoxidans Infection.Infection and immunity · 2023Article
- Effects of genetic and environmental variables on biofilm development dynamics inIranian journal of microbiology · 2023Article
- In Vivo Inflammation Caused byInternational journal of molecular sciences · 2023Article
- Genome of the epiphytic bacteriumBiotechnology reports (Amsterdam, Netherlands) · 2023Article
- The Efficacy of an N-Acetylcysteine-Antibiotic Combination Therapy onBiomedicines · 2022Article
- TheMicrobiology spectrum · 2022Article
- Article
- Genomic Insights into Achromobacter mucicolensMicrobiology spectrum · 2022Article
3 more citing papers are in PubMed but not listed here.
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22 authors.
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Abstract
Achromobacter xylosoxidans is an environmental opportunistic pathogen, which infects an increasing number of immunocompromised patients. In this study we combined genomic analysis of a clinical isolated A. xylosoxidans strain with phenotypic investigations of its important pathogenic features. We present a complete assembly of the genome of A. xylosoxidans NH44784-1996, an isolate from a cystic fibrosis patient obtained in 1996. The genome of A. xylosoxidans NH44784-1996 contains approximately 7 million base pairs with 6390 potential protein-coding sequences. We identified several features that render it an opportunistic human pathogen, We found genes involved in anaerobic growth and the pgaABCD operon encoding the biofilm adhesin poly-β-1,6-N-acetyl-D-glucosamin. Furthermore, the genome contains a range of antibiotic resistance genes coding efflux pump systems and antibiotic modifying enzymes. In vitro studies of A. xylosoxidans NH44784-1996 confirmed the genomic evidence for its ability to form biofilms, anaerobic growth via denitrification, and resistance to a broad range of antibiotics. Our investigation enables further studies of the functionality of important identified genes contributing to the pathogenicity of A. xylosoxidans and thereby improves our understanding and ability to treat this emerging pathogen.
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