ArticleHuman brain mapping2014
Concordance of white matter and gray matter abnormalities in autism spectrum disorders: a voxel-based meta-analysis study.
Article in Human brain mapping, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Atypical structural connectivity of language networks in autism spectrum disorder: A meta-analysis of diffusion tensor imaging studies.Autism research : official journal of the International Society for Autism Research · 2022Pooled it
- Hubs of long-distance co-alteration characterize brain pathology.Human brain mapping · 2020Pooled it
- Neuroanatomical and neurofunctional markers of social cognition in autism spectrum disorder.Human brain mapping · 2016Pooled it
- Hierarchical sparse spatiotemporal graph neural network for brain graph classification.iScience · 2026Article
- Autism Is Associated With Interindividual Variations of Gray and White Matter Morphology.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Behavioral Studies Using Large-Scale Brain Networks - Methods and Validations.Frontiers in human neuroscience · 2022Review
- Stereotypies in the Autism Spectrum Disorder: Can We Rely on an Ethological Model?Brain sciences · 2021Review
- Brain structural correlates of autistic traits across the diagnostic divide: A grey matter and white matter microstructure study.NeuroImage. Clinical · 2021Article
- Morphofunctional Alterations of the Hypothalamus and Social Behavior in Autism Spectrum Disorders.Brain sciences · 2020Review
- Exploring cortical activation and connectivity in infants with and without familial risk for autism during naturalistic social interactions: A preliminary study.Infant behavior & development · 2019Article
- Altered Neural Connectivity in Females, But Not Males with Autism: Preliminary Evidence for the Female Protective Effect from a Quality-Controlled Diffusion Tensor Imaging Study.Autism research : official journal of the International Society for Autism Research · 2019Article
- Precentral degeneration and cerebellar compensation in amyotrophic lateral sclerosis: A multimodal MRI analysis.Human brain mapping · 2019Article
- Brain structural alterations are distributed following functional, anatomic and genetic connectivity.Brain : a journal of neurology · 2018Article
- The morphometric co-atrophy networking of schizophrenia, autistic and obsessive spectrum disorders.Human brain mapping · 2018Article
- Recognizing visual speech: Reduced responses in visual-movement regions, but not other speech regions in autism.NeuroImage. Clinical · 2018Article
- Frontal networks in adults with autism spectrum disorder.Brain : a journal of neurology · 2016Article
- Dietary supplementation with n-3 fatty acids from weaning limits brain biochemistry and behavioural changes elicited by prenatal exposure to maternal inflammation in the mouse model.Translational psychiatry · 2015Article
- Brain/MINDS: brain-mapping project in Japan.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Sex differences in brain plasticity: a new hypothesis for sex ratio bias in autism.Molecular autism · 2015Article
- Regional brain volume differences between males with and without autism spectrum disorder are highly age-dependent.Molecular autism · 2015Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There are at least two fundamental unanswered questions in the literature on autism spectrum disorders (ASD): Are abnormalities in white (WM) and gray matter (GM) consistent with one another? Are WM morphometric alterations consistent with alterations in the GM of regions connected by these abnormal WM bundles and vice versa? The aim of this work is to bridge this gap. After selecting voxel-based morphometry and diffusion tensor imaging studies comparing autistic and normally developing groups of subjects, we conducted an activation likelihood estimation (ALE) meta-analysis to estimate consistent brain alterations in ASD. Multidimensional scaling was used to test the similarity of the results. The ALE results were then analyzed to identify the regions of concordance between GM and WM areas. We found statistically significant topological relationships between GM and WM abnormalities in ASD. The most numerous were negative concordances, found bilaterally but with a higher prevalence in the right hemisphere. Positive concordances were found in the left hemisphere. Discordances reflected the spatial distribution of negative concordances. Thus, a different hemispheric contribution emerged, possibly related to pathogenetic factors affecting the right hemisphere during early developmental stages. Besides, WM fiber tracts linking the brain structures involved in social cognition showed abnormalities, and most of them had a negative concordance with the connected GM regions. We interpreted the results in terms of altered brain networks and their role in the pervasive symptoms dramatically impairing communication and social skills in ASD patients.
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Registered trials
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