ArticleG3 (Bethesda, Md.)2013
Maternal loss of miRNAs leads to increased variance in primordial germ cell numbers in Drosophila melanogaster.
Article in G3 (Bethesda, Md.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Abundant small RNAs in the reproductive tissues and eggs of the honey bee, Apis mellifera.BMC genomics · 2022Article
- Proper Balance of Small GTPaseInternational journal of molecular sciences · 2021Article
- Maternal Piwi regulates primordial germ cell development to ensure the fertility of female progeny in Drosophila.Genetics · 2021Article
- Distinct and Coordinated Regulation of Small Non-coding RNAs by E2f1 and p53 DuringFrontiers in cell and developmental biology · 2021Article
- The multifaceted roles of microRNAs in differentiation.Current opinion in cell biology · 2020Review
- A motor neuron protective role of miR-969 mediated by the transcription factor kay.RNA biology · 2020Article
- Screening of microRNAs controlling body fat in Drosophila melanogaster and identification of miR-969 and its target, Gr47b.PloS one · 2019Article
- MicroRNA function in Drosophila melanogaster.Seminars in cell & developmental biology · 2017Review
- MicroRNAs Establish Uniform Traits during the Architecture of Vertebrate Embryos.Developmental cell · 2017Article
- The Drosophila prage Gene, Required for Maternal Transcript Destabilization in Embryos, Encodes a Predicted RNA Exonuclease.G3 (Bethesda, Md.) · 2016Article
- MicroRNAs: From Female Fertility, Germ Cells, and Stem Cells to Cancer in Humans.Stem cells international · 2016Review
- Selection Against Maternal microRNA Target Sites in Maternal Transcripts.G3 (Bethesda, Md.) · 2015Article
- microRNAs regulate cell-to-cell variability of endogenous target gene expression in developing mouse thymocytes.PLoS genetics · 2015Article
- MicroRNAs and their roles in developmental canalization.Current opinion in genetics & development · 2014Review
- Sex-biased expression of microRNAs in Drosophila melanogaster.Open biology · 2014Article
- Functional analysis of the Drosophila embryonic germ cell transcriptome by RNA interference.PloS one · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRNAs) are posttranscriptional regulators of gene expression that may act as buffering agents to stabilize gene-regulatory networks. Here, we identify two miRNAs that are maternally required for normal embryonic primordial germ cell development in Drosophila melanogaster. Embryos derived from miR-969 and miR-9c mutant mothers had, on average, reduced germ cell numbers. Intriguingly, this reduction correlated with an increase in the variance of this quantitative phenotypic trait. Analysis of an independent set of maternal mutant genotypes suggests that reduction of germ cell number need not lead to increased variance. Our observations are consistent with the hypothesis that miR-969 and miR-9c contribute to stabilizing the processes that control germ number, supporting phenotypic robustness.
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