ArticleG3 (Bethesda, Md.)2013
Identification of pedigree relationship from genome sharing.
Article in G3 (Bethesda, Md.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- Article
- PidTools: Algorithm and web tools for crop pedigree identification analysis.Computational and structural biotechnology journal · 2024Article
- Validation of the Utility of the Genetically Shared Regions of Chromosomes (GD-ICS) Measuring Method in Identifying Complicated Genetic Relatedness.Journal of Korean medical science · 2024Article
- A novel approach of kinship determination based on the physical length of genetically shared regions of chromosomes.Genes & genomics · 2024Article
- A machine learning approach for missing persons cases with high genotyping errors.Frontiers in genetics · 2022Article
- The use of shared haplotype length information for pedigree reconstruction in asexually propagated outbreeding crops, demonstrated for apple and sweet cherry.Horticulture research · 2021Article
- Phenotypic covariance across the entire spectrum of relatedness for 86 billion pairs of individuals.Nature communications · 2021Article
- Distinguishing pedigree relationships via multi-way identity by descent sharing and sex-specific genetic maps.American journal of human genetics · 2021Article
- Estimating indirect parental genetic effects on offspring phenotypes using virtual parental genotypes derived from sibling and half sibling pairs.PLoS genetics · 2020Article
- Using whole-genome SNP data to reconstruct a large multi-generation pedigree in apple germplasm.BMC plant biology · 2020Article
- Crossover interference and sex-specific genetic maps shape identical by descent sharing in close relatives.PLoS genetics · 2019Article
- Joint Estimation of Pedigrees and Effective Population Size Using Markov Chain Monte Carlo.Genetics · 2019Article
- Pedigree reconstruction from SNP data: parentage assignment, sibship clustering and beyond.Molecular ecology resources · 2017Article
- Determination of genetic relatedness from low-coverage human genome sequences using pedigree simulations.Molecular ecology · 2017Article
- A Pipeline for Classifying Relationships Using Dense SNP/SNV Data and Putative Pedigree Information.Genetic epidemiology · 2016Article
- Pairwise Kinship Analysis by the Index of Chromosome Sharing Using High-Density Single Nucleotide Polymorphisms.PloS one · 2016Article
- How Well Do Molecular and Pedigree Relatedness Correspond, in Populations with Diverse Mating Systems, and Various Types and Quantities of Molecular and Demographic Data?G3 (Bethesda, Md.) · 2015Article
- Relationship estimation from whole-genome sequence data.PLoS genetics · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Determination of degree of relationship traditionally has been undertaken using genotypic data on individual loci, typically assumed to be independent. With dense marker data as now available, it is possible to identify the regions of the genome shared identical by descent (ibd). This information can be used to determine pedigree relationship (R), e.g., cousins vs. second cousins, and also to distinguish pedigrees that have the same Wright's relationship (R) such as half-sibs and uncle-nephew. We use simulation to investigate the accuracy with which pedigree relationship can be inferred from genome sharing for uniparental relatives (a common ancestor on only one side of their pedigree), specifically the number, position (whether at chromosome ends), and length of shared regions ibd on each chromosome. Moments of the distribution of the likelihood ratio (including its expectation, the Kullback-Leibler distance) for alternative relationships are estimated for model human genomes, with the ratio of the mean to the SD of the likelihood ratio providing a useful reference point. Two relationships differing in R can be readily distinguished provided at least one has high R, e.g., approximately 98.5% correct assignment of cousins and half-cousins, but only approximately 75% for second cousins once removed and third cousins. Two relationships with the same R can be distinguished only if R is high, e.g., half-sibs and uncle-nephew, with probability of correct assignment being approximately 5/6.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.