ArticleGenetics2013
Insight into the family of Na+/Ca2+ exchangers of Caenorhabditis elegans.
Article in Genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Review
- Anthelmintic resistance and homeostatic plasticity (Brugia malayi).Scientific reports · 2021Article
- The Mitochondrial NaFrontiers in pharmacology · 2021Article
- Article
- NCX-DB: a unified resource for integrative analysis of the sodium calcium exchanger super-family.BMC neuroscience · 2018Article
- Unconventional function of an Achaete-Scute homolog as a terminal selector of nociceptive neuron identity.PLoS biology · 2018Article
- A mathematical and computational model of the calcium dynamics in Caenorhabditis elegans ASH sensory neuron.PloS one · 2018Article
- The Neuroprotector Benzothiazepine CGP37157 Extends Lifespan inFrontiers in aging neuroscience · 2018Article
- The NCLX-type NaThe Journal of biological chemistry · 2017Article
- Nematode Sodium Calcium Exchangers: A Surprising Lack of Transport.Bioinformatics and biology insights · 2016Article
- Cell-specific proteomic analysis in Caenorhabditis elegans.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- A consistent muscle activation strategy underlies crawling and swimming in Caenorhabditis elegans.Journal of the Royal Society, Interface · 2015Article
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here we provide the first genome-wide in vivo analysis of the Na+/Ca2+ exchanger family in the model system Caenorhabditis elegans. We source all members of this family within the Caenorhabditis genus and reconstruct their phylogeny across humans and Drosophila melanogaster. Next, we provide a description of the expression pattern for each exchanger gene in C. elegans, revealing a wide expression in a number of tissues and cell types including sensory neurons, interneurons, motor neurons, muscle cells, and intestinal tissue. Finally, we conduct a series of behavioral and functional analyses through mutant characterization in C. elegans. From these data we demonstrate that, similar to mammalian systems, the expression of Na+/Ca2+ exchangers in C. elegans is skewed toward excitable cells, and we propose that C. elegans may be an ideal model system for the study of Na+/Ca2+ exchangers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.